"I would say that there are thousands of Americans in jail today on the basis of far less evidence than there is against Amanda Knox," Dershowitz, a Harvard Law professor, said.
"One, she first admitted she was at the crime scene and then denied it. Second, she falsely accused somebody who was totally innocent of committing the murder. Third, she turned off her cell phone during the relative period of time. Fourth, there was DNA found underneath the bra strap and on the knife.
"It wasn't enough to establish conclusively that it was hers, but it certainly pointed in that direction. There was a pool of blood with a footprint and the man who was convicted of the murder blamed it on her, testified against her, the court found that it couldn't have been done by one person, it had to be done by at least two people."
But whether Italy can compel Knox — dubbed "Foxy Knoxy" by the press — to return is up in the air, according to Dershowitz.
"Legally, she should be required if her conviction is affirmed, but she has been conducting an incredibly successful media campaign," he said.
"I have to tell you, in 50 years of practicing law, I had never seen a more one-sided presentation by the media in the United States of the case. Everybody is saying there's no evidence against her and she's totally innocent. It's just not true."
In America, everybody's ignoring the victim, everybody is pretending as if the Italian court system is the Iranian court system, and as if they made up all of the evidence against her."
As to why he believes that is so, Dershowitz said:
"One word: she's pretty and she doesn't look like she did it and Americans care about what people look like. She's the all-American young woman and we don't care about the evidence."
"If I were the family of the victim here, I would be outraged at the way the American media is treating this case.''
Likewise, Dershowitz added, Knox should be outraged by the coverage of the case in Italy.
"They're treating this case as if she's Al Capone, as if there's no question about her innocence or guilt. It's become black and white. [In] Italy, she's guilty beyond any doubt. In America, she's innocent beyond any doubt," he said.
"The truth is it's a very close case. There's a lot of evidence of guilt, there's some evidence of innocence. On balance, it's more likely than not that she did, but there's not enough evidence to prove it beyond a reasonable doubt."