Vaccine trials

[frogwoman]

I've signed onto phase 1 of a vaccine trial (not for Covid) and I'm just wondering what experience other people have had with vaccine trials. Should I be nervous about side effects or anything? Is there anything I need to be aware of when I do it?

 

[8ball]

I think anyone’s experience is likely to be very individual to them and the particular trial.
Phase 1 is often just safety but for a vaccine they’ll be after some immune response indicators etc.
Have they given you any info on this?

 

[frogwoman]

Should say that this is by the same people who did the Oxford AZ vaccine but for a different virus.

 

[frogwoman]

I think anyone’s experience is likely to be very individual to them and the particular trial.
Phase 1 is often just safety but for a vaccine they’ll be after some immune response indicators etc.
Have they given you any info on this?

They've given me a participant information sheet detailing what they are studying, possible side effects and contraindications etc. I'm trying to be deliberately vague here!

 

[8ball]

Should say that this is by the same people who did the Oxford AZ vaccine but for a different virus.

Is it another “mRNA inside chimp adenovirus” job? I think I heard they were working on more of those.

 

[frogwoman]

Is it another “mRNA inside chimp adenovirus” job? I think I heard they were working on more of those.

Yes it is!

 

[frogwoman]

Yes it is!

Might as well say it's actually the Ebola vaccine trial - for 2 different ebola viruses at the same time.

 

[gentlegreen]

Might as well say it's actually the Ebola vaccine trial - for 2 different ebola viruses at the same time.

That's properly hardcore

 

[8ball]

Might as well say it's actually the Ebola vaccine trial - for 2 different ebola viruses at the same time.

My totally uninformed opinion is that I would expect a reaction broadly similar to the AZ Covid vaccine.

The fact that the Pfizer vaccine reactions were milder suggests to me that most of the reaction may be from the adenovirus - iirc it takes a bit longer for the body to start cranking through the mRNA, generating the antigens and also associated immunity.

 

[frogwoman]

My totally uninformed opinion is that I would expect a reaction broadly similar to the AZ Covid vaccine.

The fact that the Pfizer vaccine reactions were milder suggests to me that most of the reaction may be from the adenovirus - iirc it takes a bit longer for the body to start cranking through the mRNA, generating the antigens and also associated immunity.

Should I be worried about blood clots etc? I generally don't get reactions to vaccines - mine were all Pfizer

 

[8ball]

Should I be worried about blood clots etc? I generally don't get reactions to vaccines - mine were all Pfizer

Seems like a vanishingly small likelihood, but talk to them about it if you have concerns.

 

[bluescreen]

Very public-spirited of you to do this, frogwoman. Props to you.

 

[8ball]

How much are they paying?

 

[frogwoman]

How much are they paying?

£370

 

[gentlegreen]

They were saying on TWIV that they could easily hack the offending bit out of the vector - and should because it's such useful tech.

I'm tempted myself just so I could scare the crap out of antivaxers

 

[frogwoman]

They were saying on TWIV that they could easily hack the offendind bit out of the vector.

I'm tempted myself just so I could scare the crap out of antivaxers

Ooh is this discussed in the latest episode? Not listened yet. Supposedly they don't expose you to the actual ebola virus though.

 

[8ball]

£370

That’s a few Easter eggs right there.

 

[gentlegreen]

Ooh is this discussed in the latest episode? Not listened yet. Supposedly they don't expose you to the actual ebola virus though.

maybe you get a free holiday in Africa

 

[farmerbarleymow]

Supposedly they don't expose you to the actual ebola virus though.

How will they know if the vaccine works if they don't do that? Maybe they will and just not tell you.

 

[bluescreen]

How will they know if the vaccine works if they don't do that? Maybe they will and just not tell you.

No. That wouldn't be ethical. He's just winding you up.

 

[8ball]

frogwoman - do you have the study protocol number to hand?

(being a bit dim and it took a while to occur to me that it might be something I’m working on, or soon to be working on, so we might need to terminate this conversation)

 

[frogwoman]

frogwoman - do you have the study protocol number to hand?

(being a bit dim and it took a while to occur to me that it might be something I’m working on, or soon to be working on, so we might need to terminate this conversation)

I'll DM you

 

[LDC]

Should I be worried about blood clots etc? I generally don't get reactions to vaccines - mine were all Pfizer

That's not a question people on here will be able to (not should they try) to answer I expect. The clinical trials team will gve you all the info.

 

[frogwoman]

I had the screening appointment today. If I'm eligible I'll probably get it next week. I had to give a urine sample and blood samples!

 

[frogwoman]

I'm having the Ebola vaccine tomorrow

 

[bluescreen]

I'm having the Ebola vaccine tomorrow

Best of luck!

 

[farmerbarleymow]

I'm having the Ebola vaccine tomorrow

See - I was right.

 

[frogwoman]

i have to give them a stool sample tomorrow lmao?

 

[8ball]

i have to give them a stool sample tomorrow lmao?

Just nip into IKEA on the way there.

 

[frogwoman]

well ive had the vaccine, all ok so far apart from a bit of pain near the injection site