LDC
On est tous des pangolins
Thrombocytopenia - Wikipedia
Anything medical ending -penia just think small penis so deficient.
Possible serious side effects from the Astra Zeneca vaccine discussion
- Thread starter Riklet
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Anything medical ending -penia just think small penis so deficient.
Yossarian
⏭️
Ontario has now stopped administering first dozes of the AstraZeneca vaccine for a second or possibly third time, which is a bit frustrating because I put myself on the "I'd rather take my chances with AZ than wait months for another vaccine" list - they're calling it a "pause" but it's hard to see it making a comeback at this point unless there are big issues with the Pfizer and Moderna vaccines.
www.cp24.com
Ontario to stop administering first doses of AstraZeneca vaccine out of 'abundance of caution'
The Ontario government will pause administering first doses of the AstraZeneca vaccine for now amid increased reports of blood clotting.
Yossarian
⏭️
With stories like this appearing in the national media, there's probably no way the AZ vaccine is going to be used again in Canada, the government is now reassuring people who had a first dose of AZ that they shouldn't worry too much and they will probably be able to have Pfizer/Moderna for their second shot,
The government no doubt saved a lot of lives by using the AZ vaccine when there were no supplies of anything else, despite the blood clot concerns, but trying to reintroduce it at this stage might end up undermining confidence in vaccines in general.
The government no doubt saved a lot of lives by using the AZ vaccine when there were no supplies of anything else, despite the blood clot concerns, but trying to reintroduce it at this stage might end up undermining confidence in vaccines in general.
cupid_stunt
Chief seagull hater & farmerbarleymow's nemesis.
Well, this is something...
But, I don't understand this...
What were they thinking in ignoring his concerns, and not getting him in for a check up?
LDC
On est tous des pangolins
Without the full history and order of what happened and when and how it related to his condition at the time there's no way of saying if what happened was justifiable.
felixthecat
are we there yet?
Ordered someone to A&E last night (remote first contact practitioner role)
3 days post AZ, some general side effects including mild headache but has developed calf pain with swelling, proper pitting oedema swelling, difficulty taking weight though that leg. No shortness of breath or owt but still put the wind up me.
Hopefully will find out this evening if she's ok
3 days post AZ, some general side effects including mild headache but has developed calf pain with swelling, proper pitting oedema swelling, difficulty taking weight though that leg. No shortness of breath or owt but still put the wind up me.
Hopefully will find out this evening if she's ok
elbows
Well-Known Member
It sounds like the AZ vaccine was involved in the death of the BBC radio presenter.
Lisa Shaw: Vaccine role in BBC presenter's death to be probed
Lisa Shaw's family say the 44-year-old fell seriously ill days after having the AstraZeneca jab.
www.bbc.co.uk
MrSki
Who am I to say you're wrong
Just heard that on the radio. Got my second jab tomorrow but will play the low odds roulette. A gun with around a hundred thousand chambers is still worth the risk.It sounds like the AZ vaccine was involved in the death of the BBC radio presenter.
Lisa Shaw: Vaccine role in BBC presenter's death to be probed
Lisa Shaw's family say the 44-year-old fell seriously ill days after having the AstraZeneca jab.www.bbc.co.uk
It was the day after my first jab that doubts were first raised but looking back on my life I must admit to never really living a lifestyle overly concerned with health.
2hats
Dust.
Vaccine associated late thromboembolic events - a hypothesis.
FT: Scientists claim to have solved Covid vaccine blood-clot puzzle
Preprint - "Vaccine-Induced Covid-19 Mimicry" Syndrome: Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines
DOI: 10.21203/rs.3.rs-558954/v1.
FT: Scientists claim to have solved Covid vaccine blood-clot puzzle
Scientists in Germany claim to have cracked the cause of the rare blood clots linked to the Oxford/AstraZeneca and Johnson & Johnson coronavirus vaccines and believe the jabs could be tweaked to stop the reaction happening altogether.
Rolf Marschalek, a professor at Goethe university in Frankfurt who has been leading studies into the rare condition since March, said his research showed the problem sat with the adenovirus vectors that both vaccines use to deliver the genetic instructions for the spike protein of the Sars-Cov-2 virus into the body.
The delivery mechanism means the vaccines send the DNA gene sequences of the spike protein into the cell nucleus rather than the cytosol fluid found inside the cell where the virus normally produces proteins, Marschalek and other scientists said in a preprint paper released on Wednesday.
Once inside the cell nucleus, certain parts of the spike protein DNA are spliced, or split apart, creating mutant versions, which are unable to bind to the cell membrane where important immunisation takes place. The floating mutant proteins are instead secreted by cells into the body, triggering blood clots in roughly one in 100,000 people, according to Marschalek’s theory.
In contrast, mRNA-based vaccines, such as the jabs developed by BioNTech/Pfizer and Moderna, deliver the spike’s genetic material to the cell fluid and it never enters the nucleus.
“When these . . . virus genes are in the nucleus they can create some problems,” Marschalek told the Financial Times.
The rare blood-clotting reaction that has disrupted the rollout of the AstraZeneca and J&J shots has been recorded in 309 of the 33m people who have received the AstraZeneca vaccine in the UK, causing 56 deaths. In Europe, at least 142 people have experienced the blood clots out of 16m recipients of the vaccine.
In response, use of the AstraZeneca jab has been restricted or suspended in more than a dozen countries. J&J began the rollout of its vaccine in Europe with a warning on its label in April after a brief delay because of the concerns.
But Marschalek believes there is a straight forward “way out” if the vaccine developers can modify the gene sequence that codes for the spike protein to prevent it splitting apart.
J&J had already contacted Marschalek’s lab to ask for guidance and was looking at ways to adapt its vaccine to prevent splicing, he said.
The instructions for the spike protein in the J&J shot were already less prone to “splicing” than the instructions for the spike protein in the AstraZeneca jab, making the reaction less common, according to Marschalek. In the US, eight of the 7.4m recipients of the J&J shot have reported the rare reaction.
“[J&J] is trying to optimise its vaccine now,” he said. “With the data we have in our hands we can tell the companies how to mutate these sequences, coding for the spike protein in a way that prevents unintended splice reactions.”
J&J said: “We are supporting continued research and analysis of this rare event as we work with medical experts and global health authorities. We look forward to reviewing and sharing data as it becomes available.”
Some scientists have cautioned that Marschalek’s theory is one among many, and that further evidence is needed to substantiate his claims.
“There is evidence missing to show the causal chain from the splice . . . of the spike protein to the thrombosis events,” said Johannes Oldenburg, professor of transfusion medicine at the university of Bonn. “This is still a hypothesis that needs to be proven by experimental data.”
Marschalek said he had presented his lab’s findings to the German government’s Paul-Ehrlich Institute and to the country’s advisory body on vaccination and immunisation.
“They were surprised by our findings because no one was thinking about the splice problem,” he said.
Rolf Marschalek, a professor at Goethe university in Frankfurt who has been leading studies into the rare condition since March, said his research showed the problem sat with the adenovirus vectors that both vaccines use to deliver the genetic instructions for the spike protein of the Sars-Cov-2 virus into the body.
The delivery mechanism means the vaccines send the DNA gene sequences of the spike protein into the cell nucleus rather than the cytosol fluid found inside the cell where the virus normally produces proteins, Marschalek and other scientists said in a preprint paper released on Wednesday.
Once inside the cell nucleus, certain parts of the spike protein DNA are spliced, or split apart, creating mutant versions, which are unable to bind to the cell membrane where important immunisation takes place. The floating mutant proteins are instead secreted by cells into the body, triggering blood clots in roughly one in 100,000 people, according to Marschalek’s theory.
In contrast, mRNA-based vaccines, such as the jabs developed by BioNTech/Pfizer and Moderna, deliver the spike’s genetic material to the cell fluid and it never enters the nucleus.
“When these . . . virus genes are in the nucleus they can create some problems,” Marschalek told the Financial Times.
The rare blood-clotting reaction that has disrupted the rollout of the AstraZeneca and J&J shots has been recorded in 309 of the 33m people who have received the AstraZeneca vaccine in the UK, causing 56 deaths. In Europe, at least 142 people have experienced the blood clots out of 16m recipients of the vaccine.
In response, use of the AstraZeneca jab has been restricted or suspended in more than a dozen countries. J&J began the rollout of its vaccine in Europe with a warning on its label in April after a brief delay because of the concerns.
But Marschalek believes there is a straight forward “way out” if the vaccine developers can modify the gene sequence that codes for the spike protein to prevent it splitting apart.
J&J had already contacted Marschalek’s lab to ask for guidance and was looking at ways to adapt its vaccine to prevent splicing, he said.
The instructions for the spike protein in the J&J shot were already less prone to “splicing” than the instructions for the spike protein in the AstraZeneca jab, making the reaction less common, according to Marschalek. In the US, eight of the 7.4m recipients of the J&J shot have reported the rare reaction.
“[J&J] is trying to optimise its vaccine now,” he said. “With the data we have in our hands we can tell the companies how to mutate these sequences, coding for the spike protein in a way that prevents unintended splice reactions.”
J&J said: “We are supporting continued research and analysis of this rare event as we work with medical experts and global health authorities. We look forward to reviewing and sharing data as it becomes available.”
Some scientists have cautioned that Marschalek’s theory is one among many, and that further evidence is needed to substantiate his claims.
“There is evidence missing to show the causal chain from the splice . . . of the spike protein to the thrombosis events,” said Johannes Oldenburg, professor of transfusion medicine at the university of Bonn. “This is still a hypothesis that needs to be proven by experimental data.”
Marschalek said he had presented his lab’s findings to the German government’s Paul-Ehrlich Institute and to the country’s advisory body on vaccination and immunisation.
“They were surprised by our findings because no one was thinking about the splice problem,” he said.
Preprint - "Vaccine-Induced Covid-19 Mimicry" Syndrome: Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines
DOI: 10.21203/rs.3.rs-558954/v1.
elbows
Well-Known Member
Not sure why url unfurling isnt working for this link right now, but its 'blood clot vicar would have vaccine again'.
Indeliblelink
\......👁&👁......./
Levels of contamination with Heat Shock Proteins [HSP] and cytoskeletal proteins from the human cell lines used to produce the vaccine might be leading to autoimmune reactions.
www.chemistryviews.org
Here's the preprint
Impurities in AstraZeneca Vaccine Could Be Linked to Adverse Effects - ChemistryViews
Vaccine contains process-related protein impurities, according to preprint
www.chemistryviews.org
Here's the preprint
Aladdin
Well-Known Member
Sister has been told that having Pfizer after AZ may not be an option for her as there is some research to show that someone who has had a bad reaction to AZ could have a worse reaction to Pfizer.
And obviously she isnt having another AZ jab.
So advice is to continue to cocoon for a few months .
She is very disappointed and the whole thing is very depressing.
And obviously she isnt having another AZ jab.
So advice is to continue to cocoon for a few months .
She is very disappointed and the whole thing is very depressing.
cupid_stunt
Chief seagull hater & farmerbarleymow's nemesis.
I hope your sister's recovery is continuing.
There was a study in the UK that found mixing vaccines resulted in people more likely to have mild to moderate side effects from the second dose, the advice seems to remain if someone suffered a serious reaction from AZ, they should have a different vaccine for their second dose, see second link, which was last updated on 28th May 2021.
Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems
One study found antibody levels were significantly higher in people who received one dose of AstraZeneca then a Pfizer booster dose.
theconversation.com
Covid and your heart
Get the latest coronavirus updates from our experts, including what Covid-19 means for you if you have a heart or circulatory condition.
Aladdin
Well-Known Member
I hope your sister's recovery is continuing.
There was a study in the UK that found mixing vaccines resulted in people more likely to have mild to moderate side effects from the second dose, the advice seems to remain if someone suffered a serious reaction from AZ, they should have a different vaccine for their second dose, see second link, which was last updated on 28th May 2021.
Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems
One study found antibody levels were significantly higher in people who received one dose of AstraZeneca then a Pfizer booster dose.
Covid and your heart
Get the latest coronavirus updates from our experts, including what Covid-19 means for you if you have a heart or circulatory condition.www.bhf.org.uk
Sorry but we got the advice from the horses mouth.
My brother spoke directly with an expert in the UK and the advice was to wait for a few months.
As my sister had such a bad reaction to AZ .
And there is evidence that people can have a worse reaction to Pfizer if they had a bad reaction to AZ
It will come out in the next week or so.... dont take my word for it. Just wait and see.
The clear advice was from 2nd June. No AZ and no Pfizer for someone like my sister.
On the other hand...there is evidence that different vaccines can work very well together for people who have had no issues with either vaccine.
Aladdin
Well-Known Member
Ps. cupid_stunt
My sister is recovering very very slowly.
The recent health board hacking has prevented her from receiving speech and language therapy and physiotherapy.
So at a very crucial stage...the first 3 .months post stroke....she is without the supports needed.
Because of some fucking dipshit hackers in Russia.
I hope they rot in hell.
My sister is recovering very very slowly.
The recent health board hacking has prevented her from receiving speech and language therapy and physiotherapy.
So at a very crucial stage...the first 3 .months post stroke....she is without the supports needed.
Because of some fucking dipshit hackers in Russia.
I hope they rot in hell.
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cupid_stunt
Chief seagull hater & farmerbarleymow's nemesis.
cupid_stunt
Chief seagull hater & farmerbarleymow's nemesis.
beesonthewhatnow
going deaf for a living
A colleague has died from a blood clot on his brain just a few days after receiving the AZ vaccine. He was 26.
LDC
On est tous des pangolins
Shit, sorry to hear that. With the related thrombocytopenia? Under 30s are not generally supposed to be getting their first dose of AZ now, or was it his second dose?
beesonthewhatnow
going deaf for a living
First dose. I think people are trying to establish why he had AZ, and presumably if there’s a link or it’s a freak coincidence.
elbows
Well-Known Member
Italy halts AstraZeneca vaccine for under-60s
The Italian government said on Friday it was restricting the use of the AstraZeneca COVID-19 vaccine to people over the age of 60, after a teenager who had received the shot died from a rare form of blood clotting.
www.reuters.com
elbows
Well-Known Member
Table 5: Number of UK suspected thrombo-embolic events with concurrent thrombocytopenia ADRreports received for the COVID-19 Vaccine AstraZeneca by patient age up to and including 2 June 2021.
| Age range (years) | Number of reports | Number of fatal reports |
|---|---|---|
| 18-29 | 27 | 7 |
| 30-39 | 46 | 10 |
| 40-49 | 94 | 10 |
| 50-59 | 90 | 20 |
| 60-69 | 53 | 10 |
| 70-79 | 36 | 5 |
| 80-89 | 5 | 1 |
| 90-99 | 1 | 0 |
| Unknown | 20 | 3 |
| Total | 372 | 66 |
Table 6: Number of UK suspected thrombo-embolic events with concurrent thrombocytopenia ADRreports received for the Oxford University/AstraZeneca vaccine by patient sex up to and including 2 June 2021.
| Sex | Number of reports | Number of fatal reports |
|---|---|---|
| Male | 169 | 27 |
| Female | 200 | 39 |
| Unknown | 3 | 0 |
| Total | 372 | 66 |
From Coronavirus vaccine - weekly summary of Yellow Card reporting
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elbows
Well-Known Member
I note that in the EU their safety committee has concluded that people with a history of previous capillary leak syndrome shouldnt have the AZ vaccine, due to a small number of cases where this has been seen.
www.ema.europa.eu
Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 7-10 June 2021 - European Medicines Agency
Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 7-10 June 2021
www.ema.europa.eu
Yossarian
⏭️
Being banned from Broadway shows isn't a serious side effect of the AZ vaccine but it's definitely an unexpected one.
www.nytimes.com
‘Springsteen on Broadway’ is returning, but not for guests who haven’t had F.D.A.-authorized vaccines. (Published 2021)
The venue, New York’s St. James Theatre, is making no exceptions for people who are unable or unwilling to be vaccinated.
2hats
Dust.
A refereed paper (McMaster, Canada): Eight amino acids on the surface of PF4 are targeted by strongly binding adenoviral vector vaccination induced antibodies, mimicking the effect of heparin, activating platelets leading to VITT.
DOI: 10.1038/s41586-021-03744-4.
DOI: 10.1038/s41586-021-03744-4.
prunus
Tick tock.
That is an elegant study. It’ll be a job to back-engineer the source of the antibody binding sites and adjust the AV vector to remove it, but it’s not impossible on the face of it.
Aladdin
Well-Known Member
LDC
On est tous des pangolins
Any news on any of this, link or not beesonthewhatnow?
Some new info on the mRNA vaccines and myocarditis and pericarditis risks here:
COVID-19 vaccines: updates for July 2021
Revisions have been made to the information for healthcare professionals and information for UK vaccine recipients for the COVID-19 Vaccine Moderna and Pfizer/BioNTech COVID-19 vaccine following a thorough review of extremely rare reports of myocarditis and pericarditis after COVID-19...
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