Mpox - news and discussion
- Thread starter WhyLikeThis
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2hats
Dust.
There is evidence to suggest that for some decades after the original smallpox global eradication programme vaccination monkeypox spread was suppressed to degrees and it is only now, with significant numbers of populations unvaccinated against any member of this genus, that an opportunity for monkeypox has arisen.
DOI:10.1016/j.vaccine.2020.04.062.
There is also some research evidence that there may still be (at least for some people) degrees of T cell immunity to smallpox and by extension other orthopoxviruses, such as monkeypox, up to 75 years after the administration of those original smallpox vaccinations (eg Dryvax). Though it should be pointed out that others in the field dispute this.
DOI:10.1038/nm917.
In the current outbreak, UK epidemiological data may hint at degrees of reduction amongst those who received childhood smallpox vaccination before and up to around 1970 (the picture wouldn't be clear anyway because after 1948, and up to the termination of the UK programme in 1971, vaccination was optional and uptake dwindled towards the end of that period). Possibly it could still confer some level of cellular immunity, perhaps sufficient to curb an infectious episode and limit disease development for some immunocompetents in that cohort.
Obviously, a more recent vaccination would offer a better chance of reduction in disease progression.
DOI:10.1016/j.vaccine.2020.04.062.
There is also some research evidence that there may still be (at least for some people) degrees of T cell immunity to smallpox and by extension other orthopoxviruses, such as monkeypox, up to 75 years after the administration of those original smallpox vaccinations (eg Dryvax). Though it should be pointed out that others in the field dispute this.
DOI:10.1038/nm917.
In the current outbreak, UK epidemiological data may hint at degrees of reduction amongst those who received childhood smallpox vaccination before and up to around 1970 (the picture wouldn't be clear anyway because after 1948, and up to the termination of the UK programme in 1971, vaccination was optional and uptake dwindled towards the end of that period). Possibly it could still confer some level of cellular immunity, perhaps sufficient to curb an infectious episode and limit disease development for some immunocompetents in that cohort.
two sheds
Least noticed poster 2007
WHO warns people not to attack monkeys amid monkeypox outbreak
At least seven monkeys in Brazil have died after being poisoned or harmed. Police say they think people attacked them out of a misplaced fear of monkeypox.
www.nbcnews.com
Monkeypox: Lack of vaccines pauses rollout in Brighton
Stocks of the vaccine run low in the UK, with a new batch not due to arrive until next month.
www.bbc.co.uk
Stocks of the vaccine have run out in Brighton. None more due till the end of next month. So 6+ weeks away.
Booked appointments still going ahead, but none new being offered until then.
(Oddly the BBC have illustrated their article with a photo of Guy's hospital 80k from Brighton)
Glad noone has ever done a smallpox terrorism. Would the secret government stockpiles have been sufficient for that?
WhyLikeThis
Something, something, something
Nope, I want none of that.
l'Otters
.
It’s not new, it’s been around in Africa for 50 odd years.
Thesaint
Active Member
Rumour is the USA does, but as a bio weapon it has a problem it would eventually find its way back to you as well.
Appealing to my (unique) sense of humour, is the idea of monkeypox terrorism, whereby jihadist training instead of learning about AK47s or crashing planes, the jihadists have to train to sneak into western gay or BDSM clubs - the mind boggles at that thought
WhyLikeThis
Something, something, something
It does a bit.
gosub
~#
Putin Can't Fix This: Russia Struggling to Replenish Ukraine Troops
As Russia struggles to find enough troops to ramp up operations in Ukraine, Kyiv has warned that Moscow's supply lines are vulnerable.
www.19fortyfive.com
Leighsw2
strictly off the record
Hasn't there been a suggestion that the version linked to the outbreak in US and Europe may have evolved or mutated in some way compared to the ancestral versions that are still found in Africa?
2hats
Dust.
The current outbreak is clearly related to a clade from Nigeria and may have been undergoing human-to-human transmission since perhaps (at least) 2017.
For a DNA virus it appears to have picked up a lot of mutations in a very short period of time. However, rather than these being mutagenic 'attempts' by the virus to evolve around and evade the human immune system, they might be battle scars - the consequence of human immune systems inflicting damage on the virus in order to counter an infection (action of the enzyme APOBEC3).
virological.org
virological.org
e2a: WHO have officially adopted a new monkeypox naming scheme. Clade I is that originating from the Congo Basin/Central Africa (most pathogenic). Clade II is that from West Africa, split into two sub-clades of which Clade IIb is the variant driving the current (2022) outbreak.
www.who.int
Initial observations about putative APOBEC3 deaminase editing driving short-term evolution of MPXV since 2017
Initial observations about putative APOBEC3 deaminase editing driving short-term evolution of MPXV since 2017. An updated version of this report is now available as a preprint at: https://www.biorxiv.org/content/10.1101/2023.01.23.525187v1 This document is an initial report on the...
virological.org
Update to observations about putative APOBEC3 deaminase editing in the light of new genomes from USA
A brief update to this post: Initial observations about putative APOBEC3 deaminase editing driving short-term evolution of MPXV since 2017 Áine O’Toole & Andrew Rambaut Institute of Ecology and Evolution University of Edinburgh 2022-06-05 Three genome sequences from the USA (two from 2022...
virological.org
e2a: WHO have officially adopted a new monkeypox naming scheme. Clade I is that originating from the Congo Basin/Central Africa (most pathogenic). Clade II is that from West Africa, split into two sub-clades of which Clade IIb is the variant driving the current (2022) outbreak.
Monkeypox: experts give virus variants new names
A group of global experts convened by WHO has agreed on new names for monkeypox virus variants, as part of ongoing efforts to align the names of the monkeypox disease, virus and variants—or clades—with current best practices. The experts agreed to name the clades using Roman numerals. The...
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farmerbarleymow
I'm Petee's spirit animal
Poor dog. 
www.theguardian.com
Human to dog monkeypox case prompts
People with monkeypox told to isolate from animals after infection transmitted to Italian greyhound in Paris
NoXion
Craicy the Squirrel
Selfish fucking plague rat piece of shit.
How in the ever-living fuck can you go out in public when you have visible fucking pustules on your face and arms?! What an absolute scumbag. If you're that fucking desperate to stuff your stupid fat face with McDonald's crap, you can get that shit delivered.
How in the ever-living fuck can you go out in public when you have visible fucking pustules on your face and arms?! What an absolute scumbag. If you're that fucking desperate to stuff your stupid fat face with McDonald's crap, you can get that shit delivered.
Callie
Pivoting
And it's selling a song??
WhyLikeThis
Something, something, something
Second monkeypox strain found in the UK
Individual hospitalised with the virus had recently travelled to west Africa, say public health officials
New strain.
Fuck all monkeypox in the UK, now 2 separate strains. How curious.
When have we heard this line before?
farmerbarleymow
I'm Petee's spirit animal
Not unusual to see different strains popping up. From the story the person had been in West Africa and there are a number of different flavours of the virus. Hope they are OK.
WhyLikeThis
Something, something, something
Outbreaks are not common in the UK, let alone ones with different strains.
elbows
Well-Known Member
Stick you 'how curious' bullshit. Since the case in question is linked to travel to a specific area where monkeypox is known to be endemic in various animals, there is nothing too weird about this story that could be used to support your typical, tedious insinuations about man-made possibilities at this stage. But we do have to wait for further information about the strain in question before getting further into that sort of detail properly.
WhyLikeThis
Something, something, something
Fuck off.
Supine
Newt Member
Strains change over time. That isn’t a new phenomena. The new thing is the length of this spread. Due to a strain change or a reduction in pox type immunity due to vaccine hesitancy? I’m not up on the research - if anyone has any sci links post them up pls.
elbows
Well-Known Member
No chance, not on subjects involving infectious diseases and public health. You dont get to casually chuck 'how curious' into the story without question. If I've guessed incorrectly as to what you were getting at then feel free to explain what you actually meant. Perhaps I've misremembered that it was you who previously enjoyed imagining the original outbreak was a Russian attack.
8ball
Merr xmas...
Second monkeypox strain found in the UK
Individual hospitalised with the virus had recently travelled to west Africa, say public health officials
New strain.
Fuck all monkeypox in the UK, now 2 separate strains. How curious.
What’s the new one called?
One swallow does not a summer make.
Nor one case constitute an outbreak.
(Yet. Fingers crossed.)
WhyLikeThis
Something, something, something
You’re a programmer, not an infectious disease expert.
elbows
Well-Known Member
I'm an amateur, but I dont believe that professionals and highly qualified experts should have a monopoly on talking about subjects. I'm not sure I'd rank my programming skills too highly either, I could probably make fewer huge errors when talking at length about certain infectious diseases than I could when talking about a variety of programming subjects.
I'm genuinely sorry I was rude to you earlier. I got too frustrated with the 'how curious' thing. I believe you have every right to express yourself about this subject, just as much as me or anyone else, but I'd find it much less frustrating if you at least explained exactly what you were getting at rather than just vaguely insinuating something.
Reno
The In Kraut
I was lucky enough to get vaccinated for MPX here in Berlin, which is one of the biggest hotspots for the disease. I've had friends who have had it and they said that even the supposedly mild versions they suffered was one of the worst things they've been through. Many of my friends can't get the vaccine now. Germany went about it stupidly in their ever bureaucratic zeal to do things "correctly". Berlin has two thirds of the German cases but they divided up the vaccine equally between federal states and sent it to many places where it's not even needed. Then it stayed in fridges for a couple of months and during the gay pride season (the perfect super spreader opportunity) because of another bureaucratic bungle. This was all over the news at the start, then it turned out that it "just" (well mostly) affects promiscuous gay men (again) and it dropped out of the news . Too little is being done about it, only when it makes a serious impact on the general (heterosexual) population will this be taken seriously.
Puddy_Tat
naturally fluffy
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