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Portugal update

59 cases, 57 of those hospialised . Waiting for results of 83 tests. 3066 contacts being monintored by the Health Service There is a case under investigation, of a possible import of the new coronavirus from Germany / Austria. There are nine cases from Italy and two from Spain. There are six active transmission chains.
 
There's no way there's only 59 cases, if 57 have been hospitalised.

And, waiting on only 83 test results, when the UK is testing well over a 1,000 a day, and increasing capacity to do more. :hmm:
 
There's no way there's only 59 cases, if 57 have been hospitalised.

And, waiting on only 83 test results, when the UK is testing well over a 1,000 a day, and increasing capacity to do more. :hmm:

Only passing the news on from their equivalent of BBC pal. Another source says that there are 471 suspected cases, if that makes it any better, but i cant see this anywhere else and theres no follow up or definition of suspected cases. From same source ' The Covid-19 outbreak is affecting all sectors of the economy. In Portugal, the first was tourism, with a massive cancellation of reservations. In just one month, the Associação de Hotelaria de Portugal says it has recorded losses in excess of 30 percent.'
 
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Only passing the news on from their equivalent of BBC pal.

What's with this 'pal' thing?

I am not questioning you repeating official figures, I am questioning what testing is going on, because as we've seen in other countries, if you are not looking for it, you are not going to find it, then suddenly it sneaks up on you & bites your arse.
 
What's with this 'pal' thing?

I am not questioning you repeating official figures, I am questioning what testing is going on, because as we've seen in other countries, if you are not looking for it, you are not going to find it, then suddenly it sneaks up on you & bites your arse.
Pal ? Its a Manchester expression normally rotated with mate.
 
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I see the WHO has finally called it a pandemic - just after our poll swung to majority "serious". Coincidence?
... whereas johnson did a video interview today where he said a number of countries are, essentially, over reacting.
[sorry, can't find the link]
 
I see the WHO has finally called it a pandemic - just after our poll swung to majority "serious". Coincidence?

Well I did say this yesterday:

At this rate it is only a matter of time till the number of yes, serious votes in the somewhat silly poll that ended up in this thread exceed the no votes. Will this be the moment the WHO choose to finally declare a pandemic, long after most people had moved on from quibbling about the use of the term?

Oops!
 
Perhaps some health professionals (or others) can help me with this.

I don't understand what happens when someone gets this virus and recovers. At first they don't have any virus in their system, then they get infected and the virus multiplies in their system. Initially at least they don't have immunity, no one does, so the virus takes hold. What does the virus do? what does it act on? and assuming the patient recovers and develops immunity what has happened in the patient? Is it that their immune system has beaten back the virus and thus they now have immunity? or has the virus just run its course and died out naturally in that patient?
 
Perhaps some health professionals (or others) can help me with this.

I don't understand what happens when someone gets this virus and recovers. At first they don't have any virus in their system, then they get infected and the virus multiplies in their system. Initially at least they don't have immunity, no one does, so the virus takes hold. What does the virus do? what does it act on? and assuming the patient recovers and develops immunity what has happened in the patient? Is it that their immune system has beaten back the virus and thus they now have immunity? or has the virus just run its course and died out naturally in that patient?

NOT A HEALTH PROFESSIONAL (though kind of in the healthcare area - may be helping with a Covid-19 vaccine trial very shortly):

Virus gets in.
Dice roll against innate immunity system.
If virus wins dice roll, starts making more viruses by repurposing human as virus-replication kit.
Person emits viruses.
Viruses multiply in person and start popping cells.
Immune system notices.
Multiple-choice lurgee occurs. More dice are rolled.
Further emission of viruses occurs.
Assuming a double-six is not rolled, recovery occurs at some point.
Contagion ceases somewhere around here if not before.
Amount of immunity generated is currently unknown, but seems not especially powerful and not especially long-lasting from what I know at this point.
 
..
Assuming a double-six is not rolled, recovery occurs at some point.
Contagion ceases somewhere around here if not before.
Amount of immunity generated is currently unknown, but seems not especially powerful and not especially long-lasting from what I know at this point.
From that point above, (recovery) what happens to the virus units in the body? are they killed by the immune system? or do they die of their own accord because they ran out of fuel? I am sort of assuming the immune system in a patient that recovers wins and beats the virus back but I don't know.
 
From that point above, (recovery) what happens to the virus units in the body? are they killed by the immune system? or do they die of their own accord because they ran out of fuel? I am sort of assuming the immune system in a patient that recovers wins and beats the virus back but I don't know.

Those viruses are then gone, generally speaking, as far as I know. Antibodies will remain for some time to alert the immune system if any sufficiently similar virus comes along later. Effectiveness and duration varies. The virus doesn't really have "fuel" - all it really is is a set of instructions for replicating its own code and a little protein "coat" which it puts on when it goes outside a humans replication machinery.

Some viruses (like herpes) can chill in a kind of dormant state in certain cells, and cause issues elsewhere, but I think (not sure) that this is not one of them. Others may re-activate on re-infection/immune system issues (as in chicken pox becoming shingles later on).
 
Perhaps some health professionals (or others) can help me with this.

I don't understand what happens when someone gets this virus and recovers. At first they don't have any virus in their system, then they get infected and the virus multiplies in their system. Initially at least they don't have immunity, no one does, so the virus takes hold. What does the virus do? what does it act on? and assuming the patient recovers and develops immunity what has happened in the patient? Is it that their immune system has beaten back the virus and thus they now have immunity? or has the virus just run its course and died out naturally in that patient?

E2a: I should add I’m not a healthcare professional, but I did study biology and worked on research into RNA virus (and related endogenous virus) genetics for a number of years, so there is some somewhat out of date knowledge sloshing about in here somewhere I hope.

Basically: on initial infection of someone who has no immunity the virus will invade certain cells, hijack the cell’s protein factories and make copies of itself. It contains the instructions to be able to do this. Eventually the cell will rupture and release many copies of the virus per cell infected, rapidly multiplying the number of viruses in the patient.

The body recognises this as an invasion, but at the beginning has no specialised tools to deal with it - it uses its generic tools to try to eat (almost literally) all the viruses (if it can do this faster than the virus can reproduce, infection doesn't take hold, and eventually there will be no viruses left).

Assuming the virus manages to get past the naive defences (and they are pretty good at it) the infection will progress. These particular viruses attack cells by using a particular protein on the cell's surface as a 'door' (ACE2 receptor, involved in the blood pressure regulation system). These receptors are particularly common in the lining of the lungs, also gut, kidneys and heart, hence these systems are the primary sites.

The immune system is 'learning' how to recognise this virus, and making antibodies to target it - these are proteins designed to stick to the surface of the virus, which a) can directly impede the virus's function but more importantly b) flag the virus for assassination by the body's most lethal killer cells, who will target and kill all viruses they can - at this point it's basically an arms race - can the virus reproduce faster than the killer cells can kill them?

Assuming the killer cells win, eventually there are no viruses left - all killed ('eaten', broken down and excreted). The immune system will keep the antibodies in its production 'library' for some time (varies for different pathogens) - while in the library, any virus entering the body will get 'tagged' and rapidly killed by the killer cells (which are much better at it than the generic defences), this is being 'immune'.

If I remember my immunology classes correctly...
 
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Basically: on initial infection of someone who has no immunity the virus will invade certain cells, hijack the cell’s protein factories and make copies of itself. It contains the instructions to be able to do this. Eventually the cell will rupture and release many copies of the virus per cell infected, rapidly multiplying the number of viruses in the patient.

The body recognises this as an invasion, but at the beginning has no specialised tools to deal with it - it uses its generic tools to try to eat (almost literally) all the viruses (if it can do this faster than the virus can reproduce, infection doesn't take hold, and eventually there will be no viruses left).

Assuming the virus manages to get past the naive defences (and they are pretty good at it) the infection will progress. These particular viruses attack cells by using a particular protein on the cell's surface as a 'door' (ACE2 receptor, involved in the blood pressure regulation system). These receptors are particularly common in the lining of the lungs, also gut, kidneys and heart, hence these systems are the primary sites.

The immune system is 'learning' how to recognise this virus, and making antibodies to target it - these are proteins designed to stick to the surface of the virus, which a) can directly impede the virus's function but more importantly b) flag the virus for assassination by the body's most lethal killer cells, who will target and kill all viruses they can - at this point it's basically an arms race - can the virus reproduce faster than the killer cells can kill them?

Assuming the killer cells win, eventually there are no viruses left - all killed ('eaten', broken down and excreted). The immune system will keep the antibodies in its production 'library' for some time (varies for different pathogens) - while in the library, any virus entering the body will get 'tagged' and rapidly killed by the killer cells (which are much better at it than the generic defences), this is being 'immune'.

If I remember my immunology classes correctly...

Yep, I totally glossed over the ‘acquired immunity’ bit there. :oops:
 
I see the WHO has finally called it a pandemic - just after our poll swung to majority "serious". Coincidence?
elbows seen earlier today.

288340.jpg
 
..
The immune system is 'learning' how to recognise this virus, and making antibodies to target it - these are proteins designed to stick to the surface of the virus, which a) can directly impede the virus's function but more importantly b) flag the virus for assassination by the body's most lethal killer cells, who will target and kill all viruses they can - at this point it's basically an arms race - can the virus reproduce faster than the killer cells can kill them?

Assuming the killer cells win, eventually there are no viruses left - all killed ('eaten', broken down and excreted). The immune system will keep the antibodies in its production 'library' for some time (varies for different pathogens) - while in the library, any virus entering the body will get 'tagged' and rapidly killed by the killer cells (which are much better at it than the generic defences), this is being 'immune'.

If I remember my immunology classes correctly...
Thanks prunus, interesting post. What are the body's killer cells called? And does the eradication of the virus cells in someone who has recovered mean it is hard to test that someone has had the virus but is no longer infected by it? Because I was wondering if there could after a while be an army of post infection immune people available to help caring for the vulnerable groups, with no risk of infecting them.
 
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