Reno
The In Kraut
It's not about a male or female persona. The Doctor's persona hasn't been particularly gendered since Hartnell (and Cushing's IIRC) Doctor played at being a grandfather.
That strikes me as a rather odd thing to say. I think it's the other way round. A grandfatherly figure used to be seen as asexual ( past it) while it is implied that there is a romantic tension between the recent Doctors and female companions.
I take it from the above, that you're still having trouble relating to females.
In this case it only means that he can't relate to a female Doctor Who and not to female characters in general. There was the same discussion about a female James Bond here recently, which I would find idiotic. Why not just come up with a new female character who is an equivalent and finally make a decent Modesty Blaise film for instance, rather than turning established characters into equal opportunity exercises.