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Yeah, I was reading about this this morning - it looks pretty bad. :(


Hope you're doing OK.

I've been self isolating since last Monday with a cough. No temperature or any other symptoms so far. I cant get a test til next week or unless my symptoms get worse. Hoping that I just have a bronchitis type thing I get during cold weather. What is frightening is the way c19 is spreading so quickly And knowing how little it will take for hospitals to become overwhelmed.
 

However, a dire lack of testing obscures the reality in most countries and some important research indicates there may be a significant hidden death toll.

A recent study by Imperial University London in Sudan's capital Khartoum said that about 16,000 coronavirus deaths had gone unreported. This means that just 2 per cent of Covid deaths if the city of 6m people have been recorded properly.
 
Use of electron cryotomography to provide insight into the motions of the SARS-CoV-2 protein spike arising from its conformational plasticity, potentially enabling virion dynamics to be simulated directly.

 
Any more concrete news on the "South African" strain and how vaccines might not work against it? Please quote/tag me...
 
Any more concrete news on the "South African" strain and how vaccines might not work against it? Please quote/tag me...
The problem is that the spike mutations in the 501Y.V2 variant (all ten of them) are in known, or strongly suspected, CD4 T cell epitopes. In other words, that variant may undermine T cell response whether naturally acquired or conferred through [current] vaccines. Work is underway to better understand the implications of those changes.

Note that, separately, there is some (not yet peer reviewed) in vitro evidence to suggest some SARS-CoV-2 variants develop escape mutations that subvert CD8 T cell surveillance (DOI: 10.1101/2020.12.18.423507) - a clear indication that CD8+ is playing an important role in subjugating an infection.
 
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A longitudinal study (or longitudinal survey, or panel study) is a research design that involves repeated observations of the same variables (e.g., people) over short or long periods of time (i.e., uses longitudinal data).

thought I should check :)
 
Due to holiday period delays to data publication from some countries necessary to establish a UK figure, I have had to temporarily add England on its own to my graph of some European countries number of covid-19 patients in hospital.

Screenshot 2021-01-04 at 21.14.39.png
 
India has approved two vaccines -- the Oxford/AstraZeneca one and another one developed within India

Guardian headline said:
India’s approval of Covid vaccines triggers mass immunisation drive
Green light for Oxford vaccine alongside domestic Covaxin hailed as ‘decisive turning point’ by PM

Hannah Ellis-Petersen said:
At a press conference on Sunday, the drugs controller general of India said the decision to approve both the Oxford vaccine and Covaxin, which is produced by the Indian company Bharat Biotech and was part-funded by the government, had come after “careful examination” of the data.
It makes India the second country to approve emergency use of the Oxford/AstraZeneca vaccine, known as Covishield in India, after the UK gave it the green light on Wednesday

India plans to vaccinate 300 million people in its first stage of vaccinations, with priority given to 30 million frontline healthcare workers, police and members of the armed forces. The vaccine will then be given to those above the age of 50 and people suffering from co-morbidity illnesses. The vaccine will be given free of charge.
However, the approval of Covaxin was met with some concern as the vaccine is still undergoing phase 3 clinical trials and the full results of the vaccine’s efficacy have not been published.

IMO the above is a good, interesting and detailed read ...... but is Covaxin being approved prematurely?
 
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Indonesia going for a different route with it's vaccination program, inoculating working age people before the elderly, trying for herd immunity and hoping they can bump their economy earlier. Also due to Chinese vaccine not having been tested in the elderly and still awaiting approval.
As Indonesia prepares to begin mass inoculations against COVID-19, its plan to prioritise working age adults over the elderly, aiming to reach herd immunity fast and revive the economy, will be closely watched by other countries.
WHY 18-59 YEAR-OLDS FIRST?
Indonesia, which plans to begin mass inoculations with a vaccine developed by China’s Sinovac Biotech, says it does not have enough data yet of the vaccine’s efficacy on elderly people, as clinical trials underway in the country involves people aged 18-59.
“We’re not bucking the trend,” said Siti Nadia Tarmizi, a senior health ministry official, adding authorities would await recommendations from the country’s drug regulators to decide on vaccination plans for the elderly.
While Britain and the United States began immunizations with a shot developed by Pfizer Inc and its partner BioNTech that showed it works well in people of all ages, Indonesia has initial access only to the Sinovac vaccine.
The Southeast Asian country has a deal to receive 125.5 million doses of Sinovac’s CoronaVac shot, and a first batch of 3 million doses are already in the country.
Shipments of the Pfizer vaccine to the country are expected to begin from the third quarter, while a vaccine developed by AstraZeneca and Oxford University will start being distributed in the second quarter.
“I don’t think anybody can get too dogmatic about what is the right approach,” said Peter Collignon, professor of infectious diseases at Australian National University, adding that Indonesia’s strategy could slow the spread of the disease, although it may not affect mortality rates.
“Indonesia doing it different to the U.S. and Europe is of value, because it will tell us (whether) you’ll see a more dramatic effect in Indonesia than Europe or U.S. because of the strategy they’re doing, but I don’t think anybody knows the answer.”
Professor Dale Fisher from the Yong Loo Lin School of Medicine at the National University of Singapore said he understood the rationale of Indonesia’s approach.
“Younger working adults are generally more active, more social and travel more so this strategy should decrease community transmission faster than vaccinating older individuals,” he said.
“Of course older people are more at risk of severe disease and death so vaccinating those has an alternative rationale. I see merit in both strategies.”

WILL IT HELP ACHIEVE HERD IMMUNITY QUICKLY?
By vaccinating more socially mobile and economically active groups first, Indonesian government officials hope the government can quickly reach herd immunity.
Budi Gunadi Sadikin, Indonesia’s health minister, said the country needs to vaccinate 181.5 million people, or roughly 67% of its population, to reach herd immunity, and requires almost 427 million doses of vaccines, assuming a double-dose regimen and a 15% wastage rate.
Some experts are skeptical about reaching herd immunity, as more research needs to be done to ascertain whether or not vaccinated people can transmit the virus.
“There could be the risk of people still capable of spreading the disease to the others,” said Hasbullah Thabrany, chief of the Indonesian Health Economic Association.

WILL IT HELP ECONOMIC RECOVERY?
Economists have argued a successful vaccination programme covering around 100 million people will help jumpstart the economy, as they are more likely to resume economic activity such as spending and production.
Faisal Rachman, an economist with Bank Mandiri, said that the 18-59 age group has consumption needs that are higher than other groups.
“They could jack up the economic recovery faster because household consumption contributes more than 50% to Indonesia’s economy,” he said, warning that rising COVID-19 cases in the country could also risk lowering people’s confidence.
The pandemic pushed Indonesia, Southeast Asia’s largest economy, into its first recession in more than two decades last year, with the government estimating a contraction of as much as 2.2%.
 
Indonesia going for a different route with it's vaccination program, inoculating working age people before the elderly, trying for herd immunity and hoping they can bump their economy earlier. Also due to Chinese vaccine not having been tested in the elderly and still awaiting approval.
Interesting (though potentially expensive) experiment to find out whether the Sinovac's CoronaVac actually prevents transmission and not just severe disease...
 
Indeed. I'm finding it hard not to jump to very bad conclusions about what was meant.
This fruitloop has been posting varying degrees of weirdness.
And they have a good grasp of English so they know what they're posting
 
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