Possible vaccines/treatment(s) for Coronavirus

[platinumsage]

 

[LDC]

If people want to have a look at what it's used for now....

Dexamethasone | Drugs | BNF content published by NICE

View dexamethasone information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, contra-indications and monitoring requirements.

bnf.nice.org.uk

 

[cupid_stunt]

I was just about to post about that, as it's been on the BBC TV news.

Coronavirus: Dexamethasone proves first life-saving drug

Patients should be given the cheap drug without delay, after "fantastic" trial results, experts say.

www.bbc.co.uk

 

[Teaboy]

It certainly seems like some positive news and we could really do with some.

I don't think I'll be getting my hopes up too much yet as there is a long way to go and the numbers are good but not brilliant

 

[sojourner]

So the really deadly part of the virus is the body's inflammatory response. Do we know yet if people who usually suffer from inflammatory responses/conditions (insect bites, eczema, asthma, arthritis, gum disease) are more likely to be badly affected? Does it work like that?

 

[LDC]

So the really deadly part of the virus is the body's inflammatory response. Do we know yet if people who usually suffer from inflammatory responses/conditions (insect bites, eczema, asthma, arthritis, gum disease) are more likely to be badly affected? Does it work like that?

Inflammatory response not one thing though, much more complex than that. Suspect the answer is we don't know yet.

 

[Teaboy]

Well, they seem to be getting quite excited about Dexamethasone in today's briefing. I suppose when you scale the numbers up that's a lot of lives saved, potentially.

Given its a cheap drug as well the potential for use around the world is huge albeit it in a hospital setting.

 

[Supine]

Given its a cheap drug as well the potential for use around the world is huge albeit it in a hospital setting.

It was only found to help people on ventilators or oxygen. It didn't have a significant effect on less poorly people so hospital settings is where it'll be used.

 

[MickiQ]

I don't wish to appear cynical here but surely the fact that there is some positive news to announce and BoZo decided to do todays briefing himself is pure co-incidence.

 

[Supine]

I don't wish to appear cynical here but surely the fact that there is some positive news to announce and BoZo decided to do todays briefing himself is pure co-incidence.

Absolutely no coincidence i'd imagine

 

[weltweit]

Good news about dexamethasone.

https://www.bbc.co.uk/news/live/world-53059487 "the drug dexamethasone which could save the life of one in eight patients who experience serious breathing problems is widely available and cheap."

 

[Supine]

Good news about dexamethasone.

https://www.bbc.co.uk/news/live/world-53059487 "the drug dexamethasone which could save the life of one in eight patients who experience serious breathing problems is widely available and cheap."

Do you read this thread?

 

[weltweit]

Do you read this thread?

Yes, I did read the thread but I had just constructed a large post about dexamethasone and remdesivir and in the end decided to abandon it but I couldn't bring myself to delete all of it so I left in the bit about 1 in 8 ..

 

[rutabowa]

If people want to have a look at what it's used for now....

Dexamethasone | Drugs | BNF content published by NICE

View dexamethasone information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, contra-indications and monitoring requirements.

bnf.nice.org.uk

Oh I used to have those eye drops.

 

[LDC]

The trial has been going on for ages, and finished recently with results announced.

Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 — RECOVERY Trial

Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on dexamethasone, 16 June 2020

www.recoverytrial.net

 

[weltweit]

LynnDoyleCooper can we take it Convalescent plasma didn't have a positive effect, or does the trial continue?

 

[LDC]

LynnDoyleCooper can we take it Convalescent plasma didn't have a positive effect, or does the trial continue?

No idea, I'll have a look about.

 

[weltweit]

No idea, I'll have a look about.

No don't worry I might check it out tomorrow.
The plasma trial was in the same UK NHS trial as the dexamethasone.

 

[Supine]

No don't worry I might check it out tomorrow.
The plasma trial was in the same UK NHS trial as the dexamethasone.

Still ongoing as far as I know. They seem to be releasing results super early so I guess we'll find out as soon as they have enough patients processed.

 

[LDC]

LynnDoyleCooper can we take it Convalescent plasma didn't have a positive effect, or does the trial continue?

Trial ongoing weltweit

Research and trials

NHS Blood and Transplant is involved in a number of COVID-19 research programmes, including clinical trials investigating whether plasma transfusions could improve a COVID-19 patient’s recovery.

www.nhsbt.nhs.uk

E2A: Ah, already posted and seen.

 

[cupid_stunt]

The Houston Memorial Medical Centre seems to think they have found the answer, having a 100% success rate over 3 months, recently dropped to 96%, which is still bloody impressive. Worth reading the full article.

Dr Varon admits he's "thrown the kitchen sink" at trying to find new ways of beating this virus.

And now he thinks there's a game-changer.

He and a group of medical colleagues from five different hospitals across America have created a cocktail of commonly but separately-used drugs they're calling the Math+ protocol - and the combination is having some staggering results.

Math+ includes cortisone steroid, vitamins and anti-coagulants to try to curb the key challenges caused by the virus - blood clotting and inflammation.

"We've been doing it for a few months now,' Dr Varon said, and "it's working a charm".

He very much believes the hospital's 100% success rate for nearly three months is down to Math+.

Coronavirus: Houston doctor says 'we're heading to pure hell' as COVID-19 cases spike in Texas

A doctor tells Sky News they are receiving many more sick patients and are bracing themselves for a "tsunami" of infections.

news.sky.com

 

[prunus]

The Houston Memorial Medical Centre seems to think they have found the answer, having a 100% success rate over 3 months, recently dropped to 96%, which is still bloody impressive. Worth reading the full article.

Coronavirus: Houston doctor says 'we're heading to pure hell' as COVID-19 cases spike in Texas

A doctor tells Sky News they are receiving many more sick patients and are bracing themselves for a "tsunami" of infections.

news.sky.com

This has been around for a while now, maybe 6 weeks? Anyone who wants the details: https://www.evms.edu/media/evms_pub...cine/EVMS_Critical_Care_COVID-19_Protocol.pdf - including what they I emphasise speculate is a prophylactic dosage of mostly vitamins and zinc.

They’re using a different anti inflammatory steroid to the one the Recover study recently showed to have dramatic effect, possibly incorporating or swapping in this might be even more efficacious - I speculate this time. (Edit to add: though then they’d have to rename it Dath+ for dexamethazone instead of methylprednisolone, or, if they used the first 2 letters of dexamethazone instead of just the D, then..)

 

[Badgers]

 

[cupid_stunt]

Here's a possible treatment for those admitted to hospital, although it's early days, the double-blind trial only involved 101 patients, and the research hasn't been peer-reviewed yet, but it sounds promising.

The preliminary results of a clinical trial suggest a new treatment for Covid-19 dramatically reduces the number of patients needing intensive care, according to the UK company that developed it.

The treatment from Southampton-based biotech Synairgen uses a protein called interferon beta which the body produces when it gets a viral infection.

The protein is inhaled directly into the lungs of patients with coronavirus, using a nebuliser, in the hope that it will stimulate an immune response.

The initial findings suggest the treatment cut the odds of a Covid-19 patient in hospital developing severe disease - such as requiring ventilation - by 79%.

Patients were two to three times more likely to recover to the point where everyday activities were not compromised by their illness, Synairgen claims.

It said the trial also indicated "very significant" reductions in breathlessness among patients who received the treatment.

In addition, the average time patients spent in hospital is said to have been reduced by a third, for those receiving the new drug - down from an average of nine days to six days.

Coronavirus: Protein treatment trial 'a breakthrough'

Synairgen says preliminary results suggest its nebuliser treatment can lower the risk of disease.

www.bbc.co.uk

 

[LDC]

Here's a possible treatment for those admitted to hospital, although it's early days, the double-blind trial only involved 101 patients, and the research hasn't been peer-reviewed yet, but it sounds promising.

Coronavirus: Protein treatment trial 'a breakthrough'

Synairgen says preliminary results suggest its nebuliser treatment can lower the risk of disease.

www.bbc.co.uk

Discussed on Radio 4 this morning, and there was an interview with the head of the program. Inhaled version which is new, but the drug itself used in different formulations for MS already.

 

[two sheds]

Here's a possible treatment for those admitted to hospital, although it's early days, the double-blind trial only involved 101 patients, and the research hasn't been peer-reviewed yet, but it sounds promising.

Coronavirus: Protein treatment trial 'a breakthrough'

Synairgen says preliminary results suggest its nebuliser treatment can lower the risk of disease.

www.bbc.co.uk

Interesting, I wonder whether it might help treat flu and viral pneumonia too.

 

[Bahnhof Strasse]

Coronavirus: Oxford vaccine triggers immune response

Study shows the vaccine is safe, but it is still too soon to know if it can stop people from being infected.

www.bbc.co.uk

So, so much want this thing to work. Worried the UK government has ordered 100m doses of it, kind of signals it won't work. But really want it to with every fibre of my being...

 

[Teaboy]

I wonder why 100 million?

I also wonder how long Oxford Uni will want their name attached to it? Its all good publicity now but at some point they'll need to give it a medical name especially when they find out that in 1% it causes a tail to grow from your forehead.

 

[cupid_stunt]

I wonder why 100 million?

I also wonder how long Oxford Uni will want their name attached to it? Its all good publicity now but at some point they'll need to give it a medical name especially when they find out that in 1% it causes a tail to grow from your forehead.

AstraZeneca will be producing it, so I assume they are responsible for it thereafter, it's already known as AZD1222.

 

[clicker]

I wonder why 100 million?

I also wonder how long Oxford Uni will want their name attached to it? Its all good publicity now but at some point they'll need to give it a medical name especially when they find out that in 1% it causes a tail to grow from your forehead.

Maybe if it doesn't give long term immunity, which they won't know yet, it could be we have a yearly vaccine (like a flu jab scenario). So makes sense to stock up . However if the govt have actually managed to order something that works and arrives is another thing.