A few quotes from last week when we heard from Dr Ben Warne, Dr Gee Yen Shin and Professor Dinah Gould (Experts in Infection Prevention and Control). From the 19th September transcript
https://covid19.public-inquiry.uk/w...1310/2024-09-19-Module-3-Day-8-Transcript.pdf
Pages 40-44:
MS CAREY: Well, no, not necessarily. Yesterday we heard from Professor Hopkins, and I asked her this:
"Do you agree that where there is an accepted risk of aerosol transmission FFP3 should be recommended?"
She didn't agree with that. She said it was complicated, and she said that evidence was weak that FFP3s protected more than FRSMs, and it made us ponder why, if the evidence was weak, there has been, running throughout the guidance, this distinction between FRSMs in one context and respirators in another.
So that's the genesis of the controversy and I'd like your help with how we've ended up in this position, if you're able to help us.
DR WARNE: A lot of the evidence for this comes from SARS, so it's about 20 years old. There is no high-quality evidence, as we would understand it, so in future modules we talk about vaccines, talk about drugs and effective treatments that undergo high quality randomised control trials, so evidence which is considered to be of a high quality and is robust.
Those kind of studies are very uncommon in infection control measures so we rely on, essentially, look-back exercises, retrospective observational studies where some people had one type of infection control intervention and another group had another.
So, in SARS, there were a number of very small studies looking at people who had surgical masks or respirators or no PPE at all, and the evidence from SARS, based on those small studies, is that some PPE is much better than none, but very few of them actually compared respirators with surgical masks.
There were two studies, they're incredibly small, and those very small studies, which are by the authors' admission of poor quality, essentially are the only basis -- the only scientific basis at the start of this pandemic by which -- is quoted in guidance both of pandemic flu preparedness and other guidance at the start of this pandemic, the rationale for using surgical masks for routine clinical care above respirators.
MS CAREY: So is a lack of high-quality trial evidence that respirators are more effective than FRSM, is that --
DR WARNE: That's right because there is essentially no high-quality evidence.
MS CAREY: Right, but there is other evidence because we heard from Professor Beggs about the studies done in lab conditions.
DR WARNE: Absolutely.
MS CAREY: What about observational studies, if that be the right -- are there any other studies that help at least try and ascertain whether respirators are better than FRSMs?
DR WARNE: There's certainly been a lot, as the pandemic has progressed, observational studies which show that FFP3 respirators or other types of respirator are associated with lower risk of transmission, particularly to healthcare workers, which are the group we're talking about. None of -- again, they are being criticised because the methodology is not rigorous, they often rely
on retrospective observational data, there are chances of bias, and so on.
But that's the quality of the evidence that we're relying on and the laboratory style evidence, what we know
a priori, you know, what we know about the first principles of these aerosols and how they're generated, has contributed to a body of evidence that's open to interpretation.
MS CAREY: If there is this lack of high-quality trial evidence, can you help why it is that we've ended up now, for a number of years, with a distinction nonetheless being drawn between FRSM in routine care and respirators for AGP procedures; why have we been following this for two decades?
DR WARNE: I think part of it is entrenchment that IPC measures are very slow to change. So once you have a standard which is establish, 15, 20 years ago, there is very little change that happens with IPC measures, particularly at any kind of pace, so "That's what we've always done, that's what we'll continue to do".
MS CAREY: I saw Professor Gould nodding there. As someone who has been involved in the educational side of things, do you have a view about what Dr Warne's just told us?
PROFESSOR GOULD: I think, by tradition, infection prevention people are very traditional and they are not very forward-thinking people, they tend to be backward-thinking people, they tend to be, "We've always done it this way and it's the safe way and so we'll carry on doing it the safe way". They don't think it for any malicious reason; people don't dare to change.
So there are some entrenched things that we do and we do them because we've always done them because we just don't dare to change. We always wear masks in operating theatres because we always have. Some kinds of surgery, it's probably very unlikely that transmission of infection would occur by that route but we still wear them just to be sure.