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Coronavirus in the UK - news, lockdown and discussion

I can distinctly remember a sugar lump around 1965 -ish, but there's nothing on my record ... :hmm:

08-Jun-1961 First polio vaccination

23-Aug-1962 Booster polio vaccination

01-Sept-1976 booster polio vaccination
 
Time was that a government would have made a decision about whether everybody needed vaccinating (except those that couldn’t be) and mandated it. I offer no view on whether that is a better approach or not but it certainly demonstrates that the current neoliberal “personal choice is everything and the free market of ideas will win out” assumption is not an inevitable and only approach. It doesn’t have to be about persuading each individual that it is in their personal best interests to do something.
How would the government go about persuading people who were anti vaccination to get their mandatory vaccine? Threaten them with fines, prison? Now we're back to carrot and stick. It's better to have a small carrot than a big stick I would say.

I don't buy this whole "communities are collapsing" thing, was it so much better in the old days when open racism and homophobia was the norm? 🤔

If the disease was lethal to young people and did nothing to the elderly then I bet the vaccine take-up percentages would be reversed.
 
I freely admit that I'm possibly, very, embarrassingly, wrong to say this: but I just don't trust these daily figures anymore. I cannot see how the virus has receded such from the weekend of 50+k cases right on the cusp of the 19th. Yet here we are being told that's happening.
The new case numbers are still very, very high though.
 
Telegraph giving clear indication the booster/3rd dose will start next month. A detailed enough story to suggest it is true, shy of a u turn. Also, that it may be a different vaccine than the one you had for 1st and 2nd:
 
Totally, they could have more publicly and clearly linked loosening restrictions to % of the population vaccinated, and made it feel like a collective effort to get vaccinated and be part of things improving for everyone.
The other thing is (as with self-isolation and other things) to provide better support.

I have a job with relatively flexible working hours, that said that it would allow staff to use work time to get vaccinated, and where I live I have good public transport access to the vaccination centre - even so it took most of a morning for be to get vaccinated (and then some time to get over he side effects).

If you are doing hourly paid work and live in the "wrong" place getting vaccinated could cost a day's work. That will be a big deal for some people.
 
Telegraph giving clear indication the booster/3rd dose will start next month. A detailed enough story to suggest it is true, shy of a u turn. Also, that it may be a different vaccine than the one you had for 1st and 2nd:

looks like flu jabs are going to be a regular thing too - and at a lower age threshold ...
all adults aged 50 years and over

The JCVI’s interim advice is that a third booster jab is offered to the following groups in 2 stages:


Stage 1. The following people should be offered a third dose COVID-19 booster vaccine and the annual influenza vaccine as soon as possible from September 2021:


  • adults aged 16 years and over who are immunosuppressed
  • those living in residential care homes for older adults
  • all adults aged 70 years or over
  • adults aged 16 years and over who are considered clinically extremely vulnerable
  • frontline health and social care workers

Stage 2. The following people should be offered a third COVID-19 booster vaccine as soon as practicable after stage 1 with equal emphasis on deployment of the influenza vaccine where eligible:


  • all adults aged 50 years and over
  • all adults aged 16 to 49 years who are in an influenza or COVID-19 at-risk group as outlined in the Green Book
  • adult household contacts of immunosuppressed individuals
 
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The new case numbers are still very, very high though.
So it's like we're in the Twilight Zone, it feels. The case rate isn't good. But the vaccine has had an effect that, while welcome, has allowed the cranks now in charge of policy to unfetter everything and leave all of us high and dry.

I personally feel a bit lost. I'm uncertain how or when to move forward (probably have the issue forced when the next brown envelope from the DWP arrives).

But that's just me. At least I'm not dead or Long Covidified
 
Telegraph giving clear indication the booster/3rd dose will start next month. A detailed enough story to suggest it is true, shy of a u turn. Also, that it may be a different vaccine than the one you had for 1st and 2nd:

On Friday I got a slightly stressed email from the PCN I was vaccinating for asking for our availability from September for the booster program...
 
Question about the way efficacy is reported: when they say “two jabs are shown to have 90% efficacy against being hospitalised”, is that a relative or absolute efficacy? In other words, does it reduce the basal rate by 90%, to result in 10% of something that was already low in the first place? Or are they saying that the hospitalisation rate is now 10%? I’m assuming the former (ie relative reduction), but the way the stories are written often contextually implies the latter.
 
Question about the way efficacy is reported: when they say “two jabs are shown to have 90% efficacy against being hospitalised”, is that a relative or absolute efficacy? In other words, does it reduce the basal rate by 90%, to result in 10% of something that was already low in the first place? Or are they saying that the hospitalisation rate is now 10%? I’m assuming the former (ie relative reduction), but the way the stories are written often contextually implies the latter.
The hospitalisation rate was never as high as 10% before was it? It's surely just journalists misunderstanding statistics.
 
Question about the way efficacy is reported: when they say “two jabs are shown to have 90% efficacy against being hospitalised”, is that a relative or absolute efficacy? In other words, does it reduce the basal rate by 90%, to result in 10% of something that was already low in the first place? Or are they saying that the hospitalisation rate is now 10%? I’m assuming the former (ie relative reduction), but the way the stories are written often contextually implies the latter.

My understanding is it is a relative reduction. I am neither a statistician nor very good at maths either, but that has always been my understanding; vaccination significantly reduces my risk of hospitalisation and death and reduces to a much smaller extent my risk of transmitting it to others. I have thought a lot of the messaging around vaccination has been very poor, with a lot of people thinking it means they can never catch it or pass it on. This hasn’t helped in understanding around why despite vaccination, social distancing measures should be maintained.
 
Question about the way efficacy is reported: when they say “two jabs are shown to have 90% efficacy against being hospitalised”, is that a relative or absolute efficacy? In other words, does it reduce the basal rate by 90%, to result in 10% of something that was already low in the first place? Or are they saying that the hospitalisation rate is now 10%? I’m assuming the former (ie relative reduction), but the way the stories are written often contextually implies the latter.
Long story short it's relative risk reduction. You reduce your risk by 90% compared to not having the vaccine, but it has nothing to do with how many people will actually get hospitalised in the real world.

 
I assumed it meant for argument sake.

Pre vaccination, if you caught coronavirus you had a 3% chance of being hospitalised
Post vaccination with an assumed efficacy of 90%, you now have a 0.3% chance of being hospitalised.

Obviously as an average applied to a population, not taking into account the local prevalence, your medical history, work / living conditions and the 3% figure is one I made up...
 
My understanding is it is a relative reduction. I am neither a statistician nor very good at maths either, but that has always been my understanding; vaccination significantly reduces my risk of hospitalisation and death and reduces to a much smaller extent my risk of transmitting it to others. I have thought a lot of the messaging around vaccination has been very poor, with a lot of people thinking it means they can never catch it or pass it on. This hasn’t helped in understanding around why despite vaccination, social distancing measures should be maintained.

Absolutely it’s relative - and importantly at a population level - it means that for every 10 unvaccinated people hospitalised only 1 vaccinated person will be (matching the groups for age and other risk factors etc).

What that means for any individual is not as clear yet (and difficult to work out) - on average over the population it’s a 90% reduction, but it might be that some people are effectively immune but others only have say a 50% reduction in their personal risk.
 
So in the last week I met up with a family for something. The whole family had 'a cold', and one of them was coughing. But they had taken lateral flow tests, so were confident it wasn't covid :facepalm: I had to point out that if you have symptoms you need to get a pcr test. They were actually quite embarassed when I pointed it out and said the symptoms had snuck up on them and they hadn't thought about it enough. It got me thinking about the covid cases that might not be getting tested at the moment. People might be confusing it for a cold and not worrying about it. The symptoms might be quite mild because of vaccination (this family was double jabbed) so people are more inclined to dismiss it as a cold. And if this family were using lfts to test mild symptoms then probably lots of other people are too, and getting false negatives.
 
This thing about the % effectiveness can really easily be confusing, not just because of the confusion about whether it's relative or not but because sometimes the % given is to do with death, sometimes hospitalisation, etc etc.

What I'd really like is a big table with age groups down one side, death/hospitalisation/symptomatic/transmission along the other, and then in each box the absolute risk for unvaccinated/one does/two doses. Even with lots of caveats about uncertainties it would help to get a handle on things.
 
So in the last week I met up with a family for something. The whole family had 'a cold', and one of them was coughing. But they had taken lateral flow tests, so were confident it wasn't covid :facepalm: I had to point out that if you have symptoms you need to get a pcr test. They were actually quite embarassed when I pointed it out and said the symptoms had snuck up on them and they hadn't thought about it enough. It got me thinking about the covid cases that might not be getting tested at the moment. People might be confusing it for a cold and not worrying about it. The symptoms might be quite mild because of vaccination (this family was double jabbed) so people are more inclined to dismiss it a cold. And if this family were using lfts to test mild symptoms then probably lots of other people are too, and getting false negatives.

I know that lfts are intended for use on people without symptoms but does this mean that they're ineffective on people who have symptoms? Or just that they're not as effective as PCRs? I have had a cold that I have several reasons to believe is not covid and did several lfts but was a bit busy to go for a pcn. We're the lfts entirely pointless?
 
Weekend anecdote (second hand) - friend who says they were not going to get the vaccine due to vague "sticking it to the man" reasons mixed up with some fairly standard anti-vax "safety concerns". This led to an argument, some tears and a bit of a fall-out, then the next morning further discussions and a making up of sorts. A few hours later a whatsapp message saying they'd decided to go and get vaccinated after all :thumbs:
 
I know that lfts are intended for use on people without symptoms but does this mean that they're ineffective on people who have symptoms? Or just that they're not as effective as PCRs? I have had a cold that I have several reasons to believe is not covid and did several lfts but was a bit busy to go for a pcn. We're the lfts entirely pointless?
I think it's just that they are less reliable... if you get a positive result with LFT then it's probably correct, but if you get a negative result it's likely that it's incorrect.
 
I know that lfts are intended for use on people without symptoms but does this mean that they're ineffective on people who have symptoms? Or just that they're not as effective as PCRs? I have had a cold that I have several reasons to believe is not covid and did several lfts but was a bit busy to go for a pcn. We're the lfts entirely pointless?
my s-i-l's m-i-l was coughing and coughing and did a lft which came back positive, so i think they do work on people with symptoms as well as people without
 
Question about the way efficacy is reported: when they say “two jabs are shown to have 90% efficacy against being hospitalised”, is that a relative or absolute efficacy? In other words, does it reduce the basal rate by 90%, to result in 10% of something that was already low in the first place? Or are they saying that the hospitalisation rate is now 10%? I’m assuming the former (ie relative reduction), but the way the stories are written often contextually implies the latter.
Relative.
 
I know that lfts are intended for use on people without symptoms but does this mean that they're ineffective on people who have symptoms? Or just that they're not as effective as PCRs? I have had a cold that I have several reasons to believe is not covid and did several lfts but was a bit busy to go for a pcn. We're the lfts entirely pointless?
You can't say they're entirely pointless, they do catch people with symptoms too, but their false negative rate is very high. Testing symptomless people this doesn't matter (too much) because you wouldn't catch any cases without testing, while with testing you might catch about half of all cases. Once you have symptoms that might match, and the probability of you having it is much higher, a false negative is a dangerous thing.
 
You can't say they're entirely pointless, they do catch people with symptoms too, but their false negative rate is very high. Testing symptomless people this doesn't matter (too much) because you wouldn't catch any cases without testing, while with testing you might catch about half of all cases. Once you have symptoms that might match, and the probability of you having it is much higher, a false negative is a dangerous thing.
What about seven negatives over the course of a week all performed rigorously, gag reflex thoroughly tested and swab almost into the brain etc. And the other person in the house with the same symptoms has had two negative pcns? What then?
 
This is worth a read.

PHE Porton Down’s labs have shown four lateral flow tests to have a sensitivity of more than 70% for all PCR positive cases but, importantly, they are able to catch those with high viral loads, suggesting they are effective in identifying cases that are most likely to transmit the disease.

 
What about seven negatives over the course of a week all performed rigorously, gag reflex thoroughly tested and swab almost into the brain etc. And the other person in the house with the same symptoms has had two negative pcns? What then?
I'm not enough of a statistician to know how the maths of false negatives versus genuine negatives accumulates through multiple tests (it might also depend on the mechanism of failure). It also seems a lot of trouble to go to when you could have one pcn delivered and send it off.
 
What about seven negatives over the course of a week all performed rigorously, gag reflex thoroughly tested and swab almost into the brain etc. And the other person in the house with the same symptoms has had two negative pcns? What then?
stopped bothering with the tonsil bit, just keep the swab a bit longer up the nose.
 
I know that lfts are intended for use on people without symptoms but does this mean that they're ineffective on people who have symptoms? Or just that they're not as effective as PCRs? I have had a cold that I have several reasons to believe is not covid and did several lfts but was a bit busy to go for a pcn. We're the lfts entirely pointless?
Aren’t you only meant to get a PCR if you have either a positive LFT or have the symptoms they list (fever, continuous cough or loss of taste/smell). Even if you have a cold, unless you have the above, I don’t think you are meant to have a PCR. Obviously you can lie and get one.
 
Aren’t you only meant to get a PCR if you have either a positive LFT or have the symptoms they list (fever, continuous cough or loss of taste/smell). Even if you have a cold, unless you have the above, I don’t think you are meant to have a PCR. Obviously you can lie and get one.
Or if youve had contact with a positive person.
 
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