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Omicron news

Nottinghamshire County Council said investigations into the spread of the variant locally were being carried out at a school in West Bridgford.

Jonathan Gribbin, director of public health for Nottinghamshire, did not name the school but said the parents of students had been informed.

 
The UK Health Security Agency (UKHSA) has identified 2 further cases of COVID-19 with mutations consistent with B.1.1.529 in England, in addition to the previous 3 confirmed cases of the SARS-CoV-2 variant known as B.1.1.529 on 27 and 28 November. The total number of confirmed cases in England is now 5.

The individuals that have tested positive are not connected to each other and are not linked to the previously confirmed cases. Both have links to travel to Southern Africa. One case is located in Camden, London, and one case is located in Wandsworth, London. The individuals and their households have been told to self-isolate. UKHSA is carrying out targeted testing at locations where the positive cases were likely to be infectious.

 
Depressingly virus' don't always evolve to become less lethal. See Ebola and MERS.

The idea is a virus that kills a large percentage of it's hosts has an evolutionary disadvantage. But there are viruses in the wild, like the above that have a 30% (roughly IIRC) lethality rate.

Granted they're unlikely to spread as far as something like coronavirus cos people die or stay out of the way. But I don't think it's a given that all virus's tend towards less lethality.
 
Portugal acted fast over omicron and just got their bottom slapped by the EU

The European Commission implicitly criticized one of the latest measures taken by Portugal. The government announced that tests will be mandatory for all travelers arriving in the country, even those who are double vaccinated.
Brussels reiterated the principle that Member States should refrain from erecting undue barriers to Covid-19 vaccinated and recovered passengers.
 
Depressingly virus' don't always evolve to become less lethal. See Ebola and MERS.

The idea is a virus that kills a large percentage of it's hosts has an evolutionary disadvantage. But there are viruses in the wild, like the above that have a 30% (roughly IIRC) lethality rate.

Granted they're unlikely to spread as far as something like coronavirus cos people die or stay out of the way. But I don't think it's a given that all virus's tend towards less lethality.

I thought MERS was a bacterial infection? Or am I confusing that with MRSA?
 
Portugal acted fast over omicron and just got their bottom slapped by the EU

I don't know why they wouldn't want to test everyone anyway, regardless of vaccination status. Why leave great big gaps in biosecurity measures? Especially since vaccinated people can still be carriers.

confused as I think MERS is the viral & MRSA is bacterial.

Yeah looked it up, MERS is viral.
 
Depressingly virus' don't always evolve to become less lethal. See Ebola and MERS.
Considering the fact that deaths from Covid usually happen a considerable time after infection, it doesn't seem likely that becoming less lethal would necessarily give it an evolutionary advantage.
 
Is there a chance that if this new variant is just like a simple mild cold and it becomes the dominant world wide, that it will wipe out the worse variants and be the end of this?
 
7.40am post on the Telegraph's live update.

Stephane Bancel, chief of pharma giant Moderna, poured cold water over hopes that current vaccines will be able to handle the omicron variant. He told the FT: "There is no world, I think, where [the effectiveness] is the same level . . . we had with [the] Delta [variant].

“I think it’s going to be a material drop. I just don’t know how much because we need to wait for the data. But all the scientists I’ve talked to . . . are like, ‘This is not going to be good’.”

Mr Bancel said scientists were worried because 32 of the 50 mutations in the new strain were on the spike protein, which current vaccines focus on to boost the human body’s immune system to combat Covid.
 
Is there a chance that if this new variant is just like a simple mild cold and it becomes the dominant world wide, that it will wipe out the worse variants and be the end of this?

There is a chance, but it’s pretty remote and not really worth spending a second thinking about (yet - it would be a spectacular piece of luck though).

I suspect that this particular virus is still in the optimising for new host phase - ie it will be getting better at transmission and infectivity (omicron seems it may be a jump in that direction, though that may be escape mutation increasing its available pool of hosts). Many of the ways it can improve infectivity are likely to increase virulence too - basically it becomes better at invading our cells, both on first contact and when replicating inside a new host.

Lethality is complex as it is an interaction of the severity of the actual infection (the damage done by the virus itself) and the immune response (the damage done by extreme immune reaction - cytokine storms and the like). It’s not impossible that a more infectious version actually provokes a less over-the-top immune response, which will lead to fewer deaths. But it’s by no means certain, or even particularly likely.

The virus itself doesn’t ‘care’ if it kills all its hosts and die out. It just randomly changes and some of the resultant versions outcompete others and become dominant. If those versions also happen to be less lethal, jolly good. But they may also be more lethal.

In the long run there aren’t any pandemic (ie common and widespread) viruses with very high lethality not because they all become milder over time, but because the lethal ones (and the ones that became more lethal over time) have died out, taking most of their host population with them.
 
In the long run there aren’t any pandemic (ie common and widespread) viruses with very high lethality not because they all become milder over time, but because the lethal ones (and the ones that became more lethal over time) have died out, taking most of their host population with them.
Plus if there are some specific genetic traits that make some hosts much more susceptible to death from the virus in general, a lot of them may be wiped out, causing the overall population risk of death to change. Not sure how big a factor that actually is though, and there are all the hosts who are vulnerable due to other health conditions.

Some virologists end up perpetuating some of the myths too, since there is not universal agreement on all of the details and expectations, especially when people including authorities and journalists are seeking simplistic, reassuring stories and pictures of a positive future.

There are positive concepts to be found, or at least concepts with more positive end-games. For example even if the virus doesnt change, we do. In that people will have many opportunities to catch various versions of the virus when they are young and less vulnerable to the worst consequences, or even inherit some degree of protection by design or by luck. But I expect my own description of these things is also a bit sloppy and error-prone. Main point is that some of the viral evolution cliches are not grounded in fact.
 
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I hate this sort of sloppy framing:

The Omicron variant was in Europe days earlier than first believed, it emerges, with cases found in samples taken between 19 and 23 November - before it was identified in South Africa

When a case is first detected is not the same as when that variant was first believed to be here. And at this stage of the pandemic far more people were aware of that due to previous experiences with bullshit rhetoric about 'containing' recently detected variants. Rhetoric that even the UK authorities havent bothered with this time, instead going for something closer to reality by talking about slowing the spread instead.

Anyway that quote is from the BBC live updates page https://www.bbc.co.uk/news/live/59473695 and is sponsored by the Netherlands:

Health officials in the Netherlands will carry out further studies to determine when the new Omicron variant first emerged in the country.

Newly sequenced tests from two people between 19 and 23 November found the variant was present in the country before it was first identified in South Africa.
 
I'm getting a booster on the 8th, hope this Omnicron doesn't fuck things up. Name reminds me of Unicron from the 1984 Transformers film (voiced by Orson Welles)
UK authorities are using expansion and acceleration of the booster campaign as the main thrust of their initial Omicron response because:

Its viewed a bit like a tug of war - Omicron assumed to reduce vaccine efficacy but boosters can at least bump up the starting level of protection that is then eroded by the variants properties. We'll have to wait for much better data to see what the balance of these two competing factors will actually end up like.

They much prefer vaccine-based stuff to other measures, but dont be surprised if they are forced to do more of the other stuff in future too.
 
Even Harries has cast doubt on the comments about it being 'mild' from the South African doctor that peope unwisely tried to make too much of the other day.

  • She said early reports about Omicron having only a mild impact in South Africa should be treated with caution because its population was so different. She said the average age of the population in South Africa is 27. In the UK it is 41. And she said Omicron, like other coronavirus variants, is thought to be much worse for older people not younger younger.

5h ago 10:08
 
Perhaps it’s not as bad as first thought?


Would love this to be true. A mutation set for increased infectivity and milder disease out-competing the other variants would be a godsend.
 
Wouldn't not leading to an increase in deaths mean it's approximately as deadly as the other strains, rather than "super mild"?
 
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