no, it's guilt at being a bad driver
eta: here's a synopsis to save you the bother of watching it:
will smith is sad. you know it cos he's frowning and the film's first scene is a flashforward to him reporting his own suicide. then he's driving around being horrible to people. it turns out he's some kind of medical insurance claims adjustor. so you think, oh that's why he's horrible to people. he's even horrible to a blind woody harrelson. oh, and at some random point he does a soliloquy about how fascinating he found jellyfish as a kid or summat. but anyway, then he starts being nice to people. downtrodden people who need a break in life, like blinds, abused wives, sick people. then it turns out that he's not a medical bastard, but he's just pretending to be one, using his brother's credentials. people are puzzled about why he is being nice all of a sudden, including a beautiful lady with a weak heart. he fixes her printing press and they fall in love, but he's all hot and cold and she's all hurt and confused. then it transpires that he's feeling sad cos a while ago he wasn't paying attention to the road and he crashes his car, killing his wife and some people in an suv. it turns out that the number of people he's helped (guess how many?) is the exact number he's killed. then he gets in the bath filled with ice water and releases a box jellyfish. he has a hilarious fit and then dies.