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Well going on about that stuff has been a major focus of the WHOs words for a long time now. Too many powerful countries do little more than pay lip-service to the concepts though, so its a long hard slog. I might hope that more is done by countries like the UK once their own establishments 'needs' for securing a huge chunk of supply are different, but I have my doubts.

As for the notion that large unvaccinated populations are where the main threat from future variants comes from, this subject is all fucked up these days, there is double-think and contradiction aplenty that rhetoric does not take proper account of. The actual reality seems to be that there are multiple different sorts of theoretical mutation risks. For example, evolutionary theory that considers 'natural selection pressures' implies that when it comes to vaccine-evading mutations, that pressure actually increases when you have a highly vaccinated population but still huge numbers of ongoing infections. ie in order to still thrive, random mutations that can bypass immunity will end up with a big advantage that could eventually result in their dominance. So arent countries like the UK still a massive threat on that front? Other possibilities exist too, and perhaps we will get lucky eg if the virus runs out of possible mutations that make a huge difference, or those differences also change disease severity in a positive way. But I'd certainly suggest that any country which stops trying to reduce the number of infections is theoretically increasing the risk.

There might be other factors too, eg if a huge chunk of those genetically susceptible have already been killed off. And the picture of individual immunity is probably far more complex than current understanding can properly deal with. eg partial immune escape, whether thats from vaccine-induced immunity or immunity stemming from previous infections, may not be enough to prevent reinfection but may still permanently change the risk of hospitalisation and death. Not completely, but enough to stop the possible number of hospital admissions so easily and rapidly breaching the thresholds that force authorities to impose heavy restrictions.
 
With that in mind, I expect the default presumption which drive the current attitudes of authorities in various countries is very much centred around traditional thinking. ie what makes a pandemic a pandemic in the first place - a new virus that the entire global population have not met before. We are travelling beyond that phase, and so we hear about a future with endemics and epidemics instead of acute pandemic stuff.

Under those conditions and with that traditional thinking, we never quite end up all the way back to square one. Under those conditions we can still have continual deaths at lower quantities, and quite possibly nasty waves every so many years that involves a more substantial spike in deaths. But the immunity picture will remain complex and nuanced, and so expectations tend to lean towards the sort of things we see when a strain of influenza bypasses some chunk of population immunity and can kill in reasonably high numbers for a period of time. Such circumstances can strain hospital capacity for periods of time, but so long as the immunity picture doesnt involve everyone being 100% naive to the virus, and so long as lots of pharmaceutical options to take the edge off it are still available, these circumstances are deemed to be largely compatible with business as usual.
 
An example of why flu deaths may be lower. January New Year 20, pre-covid, 111 advised us to take 93 year old Dad to emergency walk-in clinic with a suspected UTI. Brief consultation with GP and nothing ascertained that we hadn’t already told them. Broad spectrum antibiotics prescribed. He probably picked up influenza type A from another patient or staff there (none of his other contacts had flu). A few days later he collapsed and spent 3 weeks in hospital with flu/pneumonia. Made a good recovery and has since survived COVID.

I know there‘s not much flu about now but also old people are not forced to hang around in GP surgeries like they used to. Most prescribing done over the phone which for people like him is of benefit since less exposure to all types of bugs.
 
Yeah, it didnt make any sense to me at the time. How everything, all precautions, can just disappear overnight. When one month ago my friend was leaving shopping at my door and then running away and I spent 2 weeks isolated. Now everyone is mingling like nothing ever happened. So yolo is the only way to describe it really.

It's almost as if someone knows we are heading into a worse worldwide scenario and thinking "let's give them some freedom before it all kicks off "
 
The West Australian border is re-opening on March 3rd after almost two years. We are at over 95% double vaxxed and the booster rate is expected to be around 80% by then. After two years of practically zero covid we are now at around 250 a day and this is expected to increase rapidly, so we are all wearing masks and gearing up to WFH where we can. I thought you might be interested to see the modelling, which was released today.


More personally, this means my husband can get back to Ireland to say goodbye to his terminally ill little brother. I am very worried about him travelling, but it has to be done. Just trying to get it organised (his bloody passport is almost out of date too which we just discovered!) So fingers crossed all that works out ok, because if they change the rules and he gets stuck outside WA, we are fucked.
 
The West Australian border is re-opening on March 3rd after almost two years. We are at over 95% double vaxxed and the booster rate is expected to be around 80% by then. After two years of practically zero covid we are now at around 250 a day and this is expected to increase rapidly, so we are all wearing masks and gearing up to WFH where we can. I thought you might be interested to see the modelling, which was released today.


More personally, this means my husband can get back to Ireland to say goodbye to his terminally ill little brother. I am very worried about him travelling, but it has to be done. Just trying to get it organised (his bloody passport is almost out of date too which we just discovered!) So fingers crossed all that works out ok, because if they change the rules and he gets stuck outside WA, we are fucked.

Qld modelling was completely out in a good way, and after opening our borders on Dec 5th we've peaked, and we've rolled back a heap of restrictions and even mask mandates end next week. I hope you're as lucky, and that your husband can get away and home again with out getting locked out. McGowan is a bit trigger happy.

My head office is in WA and they really pay no attention to anything that happens on the east coast :facepalm:
They're trying to impose their new restrictions on us.. that we've actually been following for almost 3 months without them noticing.

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Schools still closed here in Bangladesh and no online learning. They're set to go back at the start of March.

Masking is done properly here too. To be fair, it's so polluted and so many flies in places that it's quite useful wearing a mask even without covid.

No idea about testing or cases, but a colleague of mine ended up stuck here due to a positive result. I will be basically isolating myself as much as possible in my last few weeks as I could not cope if I couldn't leave.
 
It has been reported for a while now including the UK (32 case mentionned in the fail a few days ago)
In other news Deer to human infection spotted in Canada.
 
Yeah sure I’ll take some random anonymous poster off the internet’s assessment of whether a variant is of concern or not.

Carry on doomscrolling then, be my guest.

But perhaps you could explain why a variant that is a combination of variants that we a) have effective vaccines for, b) have developed high population infection-acquired immunity against and c) are very much a known knowns, should be something to get more concerned about than existing variants or all the other conceivable variants that feature novel mutations?
 
I’ve never seen you post anything other than utter bollocks on this subject. If I come back and post more about this here it won’t be for your benefit. That’s a lost cause afaict.
 
Shame this study is arriving so late in the pandemic, I think it "COVID directly attacks the penis and testicles" would definitely have helped with anti-infection messaging earlier on.

The coronavirus may infect tissue within the male genital tract, new research on rhesus macaques shows. The finding suggests that symptoms like erectile dysfunction reported by some Covid patients may be caused directly by the virus, not by inflammation or fever that often accompany the disease.

 
What does it say in French? Another variant I am assuming?
A recombinant. However we now have evidence for recombination happening all the time. It's not necessarily an issue (and does not appear to be in this case). However it would be foolish to assume that a recombinant of previous VOC only inherits properties (or a subset thereof) from the parent lineages. Even small changes in nucleotide sequences can potentially bring about significant changes in pathogenicity due to the subtle (and not so subtle) interplay of variation of electrostatic forces with differing protein expression and the high degree of conformational plasticity of this particular virus. Consider, perhaps, novel protein folding arrangements that shield significant numbers of what were previously key epitopes, for example. That's not to say that will happen, or is even likely, but it would be irresponsible not to monitor it.
 
I guess everyone is distracted by Ukraine but the covid situation in Hong Kong is not getting a lot of attention - it seems to now be completely out of control there.

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I guess everyone is distracted by Ukraine but the covid situation in Hong Kong is not getting a lot of attention - it seems to now be completely out of control there.

Yeah its become a tragic and disgraceful example of what happens if you claim a zero-covid strategy but dont actually do the things necessary to implement that strategy or dont have an exit strategy that is compatible with the timing realities of a more transmissive variant.

I've gone on about merits of zero covid in the past, via things like Australias overall deaths. But I absolutely do not support zero covid when it becomes empty rhetoric not backed by appropriate policies. And policies need to get tougher in the face of more transmissive variants, and if that strength of policy isnt realistic then you absolutely have to have an exit strategy that involves at the bare minimum achieving a very high uptake of vaccines in the older age groups. And if you dont achieve that, you absolutely have to protect care home residents and the elderly in general in other ways. Hong Kong appears to have miserably failed with all of that stuff, leaving many people extremely vulnerable.

I did not want somewhere in the world to end up as a really obvious and deadly example of the largest flaws of 'Omicron is mild' thinking, but Hong Kong seems to have become that example :( There were other examples including the USA for a time but people found various ways to quibble about that, and I dont think there is much room for that sort of quibbling with the Hong Kong situation.
 
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I don't really understand how they managed to mess up on doing the one most obviously important thing - vaccinating elderly people. Especially when vaccination rates seem pretty good among the rest of the population.
 
I don't really understand how they managed to mess up on doing the one most obviously important thing - vaccinating elderly people. Especially when vaccination rates seem pretty good among the rest of the population.

It was one of the more obvious theoretical downsides of the zero-covid approach (the other being people not liking the strength of measures that approach entails). Theres always been the fear that countries and populations who were shielded via zero-covid from most of the death in earlier waves, would end up not being motivated enough to get vaccinated when the vaccination era arrived. Those fears didnt come to full fruition in most zero covid countries, but in Hong Kong it has. I havent tried to dig into the picture to determine how much of this grotesque failure was down to broad population attitudes, and how much was down to the most obvious of government and institutional failings.
 
I guess everyone is distracted by Ukraine but the covid situation in Hong Kong is not getting a lot of attention - it seems to now be completely out of control there.

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Jessiedog has been posting about this daily on the Hong Kong: what next? thread.
 
It was one of the more obvious theoretical downsides of the zero-covid approach (the other being people not liking the strength of measures that approach entails). Theres always been the fear that countries and populations who were shielded via zero-covid from most of the death in earlier waves, would end up not being motivated enough to get vaccinated when the vaccination era arrived. Those fears didnt come to full fruition in most zero covid countries, but in Hong Kong it has. I havent tried to dig into the picture to determine how much of this grotesque failure was down to broad population attitudes, and how much was down to the most obvious of government and institutional failings.
You'd think that if there was low motivation in the population you'd see it in all age groups. Somehow they have managed to end up with lower age groups quite well protected, but not older ones.
 
You'd think that if there was low motivation in the population you'd see it in all age groups. Somehow they have managed to end up with lower age groups quite well protected, but not older ones.

In theory I suppose if you'd motivated the younger population via the equivalent of 'vaccine passports' then you might see that pattern, especially if the vaccination programme wasnt pro-active in terms of the practicalities of giving easy access to vaccines for the eldery as opposed to the young and mobile. But thats just theory, I absolutely have not checked actual realities in Hong Kong.
 
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