2hats
Dust.
A case of P.1 (B.1.1.28.1, Manaus, Brazil) raising the question of whether that variant (mutations S:K417T, S:E484K, and S:N501Y) might be demonstrating immune escape (as has recently been suggested elsewhere based on modelling and laboratory studies of the E484K mutation in the presence of N501Y). Here an immunocompetent 29 year old female was reinfected with P.1 (experienced worse symptoms) nine months after previous confirmed infection with a B.1 (earlier D614G variant). She had tested positive for IgG antibodies to the first SARS-CoV-2 infection just 8 days prior to the second infection. More research is urgently required to identify and sequence P.1 (and other S:E484K) reinfections of such seropositive individuals.
SARS-CoV-2 reinfection by the new Variant of Concern (VOC) P.1 in Amazonas, Brazil
SARS-CoV-2 reinfection by the new Variant of Concern (VOC) P.1 in Amazonas, Brazil Felipe Naveca 1,2,3, Cristiano da Costa 2,4, Valdinete Nascimento 1,2,3, Victor Souza 1,2,3, André Corado 1,2,3, Fernanda Nascimento 1,2,3, Ágatha Costa 1,2,3, Débora Duarte 1,2,3, George Silva 1,2,3, Matilde...
virological.org
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