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Coronavirus in the UK - news, lockdown and discussion

There's lots of reports today about a low percentage of the world's population carrying antibodies, but I haven't seen anything about people having recovered not carrying antibodies or carrying low quantities. That would be noteworthy, but are you completely sure it is what you have seen?

Probably this: Low antibody levels raise questions about coronavirus reinfection risk

Small sample (175) and not peer reviewed yet but a third of recovered patients, notably younger ones, had much lower levels of antibodies than would be expected and 11 had none at all.
 
Listening to this now. Sadly John Ashton is frozen - looks like he's not going to appear.

Points so far. Sorry bit scattergun:

Nightingale - glad it was done but did it divert too many resources? Mostly empty so far.

The lack of testing for nurses/doctors is shocking, and is leading to community spread.

Seven-day isolation from onset of symptoms probably not wise! Confusion about why advice conflicts with that in other countries.

Mystification about test and trace. The doctors being interviewed just don't know where it is, or where it could be coming from.

Dyson ventilators not appeared yet. Nurses will need training for them anyway. But will they ever happen? A basic wtf about that.

PPE: Point about it not being just hospitals that need it, and that the biggest problem is among social care workers. Emergency stockpiles lost pre-epidemic: point made that NHS instead relied on having a 'procurement chain' in place - ie some form of 'just in time ordering' - which has now broken down due to crisis.

They're insulted by Hancock preaching at them about how to use ppe.

They've made the point about the importance of migrant key workers. Need end to hostile environment. Also point about ending the practice of hospitals giving immigrant details to the home office. Plus need to capitalise on public appreciation to fight privatisation.

Need for some spare capacity in ICU before lockdown is lifted in case of a second surge. Also, need for test and trace first.


Got bored now. Don't think John Ashton is coming.
thank you for this - saved me doing it.

I'd just add that the first speaker called for the dependents of deceased NHS workers who are migrants to be given right to stay and be supported in UK
 
I am a bit concerned about this "soft" opening this week as well that has been noted by others upthread.
Had an email from my work last week (retail), asking for volunteers to come back from furlough to support the online shopping operation which is currently being run just from a central warehouse, but is usually also fulfilled by some stores. Now in some ways this makes sense, and in fact prior to lockdown I had wondered - and even wanted - our mail order service to continue. There is certainly enough space to make the distancing very feasible if only a handful of staff are in on any given day. Otoh I strongly disagree with it because of the can of worms it opens in terms of travelling, especially in London where so many people live a long way from the centre. Now I happen to live within walking distance, but I count myself as excluded per their criteria by sharing a household with someone with increased risk (and because I am only just starting to enjoy sitting on the balcony now that I am not in perma-panic anymore!)
It was all very much couched in the language of being on a voluntary basis, and they were asking for people who can walk/bike as a priority...but then also said "or use public transport if comfortable with it". But the whole point is, it's not just about an individual's risk assessment, but about the wider effects (plus, in my understanding, Tfl are still asking to absolutely not use public transport in London, apart from actual key workers). And if this little bit is replicated amongst dozens, hundreds, thousands of businesses in London, even if it's within the parameters. .. it's a worry to me. Especially while there's no test and trace in place, and while I am sometimes getting the impression on my incredibly infrequent walks that some people haven't quite got that even with social distancing you are still not supposed to cough and sneeze at people...

It's similar to the effects of 'panic buying', which in all probability weren't really due to panic buying at all, just the cumulative effect of lots of people buying a slightly bigger pack of bog roll or an extra tin of beans. So your work's email is very much a part of a wider process of small steps, and the cumulative effect is really evident now - from two weeks ago to today, a very distinct, clear difference on the streets.

I've been on lots of walks around London in the last month, and up to this week, it's been as easy as anything to maintain a big distance scrupulously from everyone at all times on my wanderings. This week, that's not been the case. Out of courtesy, I'm waiting for people or moving aside, but I've noticed for the first time that others aren't always reciprocating. I'm struck by the rudeness of it, tbh, given the current situation.

From a purely selfish pov, my walks have lost the slightly magical edge they once had. (yeah, who cares!) But I didn't expect this change to occur so long before any formal easing of lockdown. The thing is very definitely cracking.
 
Seven-day isolation from onset of symptoms probably not wise! Confusion about why advice conflicts with that in other countries.

Originally 7 days struck me as the kind of compromise a state would reach when trying to balance between the actual infection risk, and what percentage of the workforce would be absent according to various models. I could sort of see the rationale behind it when they were mostly going for the 'anyone with any symptoms vaguely similar to Covid-19 should self-isolate'. But its not a number of days driven purely by medical knowledge, its a compromise. And then, just like with decisions to describe certain kinds of contacts as close only if they lasted at least 15 minutes, the arbitrary numbers we have chosen for a specific reason then end up getting treated as some kind of fundamental truth, rules the virus sticks to. When obviously it doesnt care about our rules and definitions. So its bloody stupid to take the 7 day value, which was a compromise for a particular situation, and then treat it as though this is the amount of time that actually confirmed cases who tested positive should isolate for, and that any longer is unnecessary.

So yeah, I would say its not wise. Its possible that they can get away with such things without it making a really large difference because so much of the transmission between people actually tends to happen earlier, in which case it would be another numbers game, another factor that went into the earlier compromise calculation. But its not what you would choose to do if you were actually trying to minimise the risk for every single person, its the sort of thing you might get away with if only looking at the very largest picture, and trying to dodge the very scariest scenarios with their terrible orders of magnitude. If tens of thousands of lives lost now matters, but hundreds still dont, all sorts of sloppy decisions can be gotten away with in that numbers game, and it is tempting for me to put the 7 days thing in that camp :(
 
Nightingale - glad it was done but did it divert too many resources? Mostly empty so far.

These places could in principle free up existing hospitals to go back to more normal stuff without worrying about sealing off specific covid wards, but only if you've got enough staff. There aren't enough staff. Also diverting all covid patients to Nightingale hospitals is unrealistic when you consider there's going to be what, five of them? A large chunk of the population will not be within viable transport distance of one.
 
I think the problem is not that we don't have an end date as such, but we just have no other plan as an alternative to lockdown which would mean we could come out of it.

It's plainly obvious to everyone, that as soon as either the govt say we can ease lockdown, or everyone just gets bored of it anyway, we're just going to see the numbers go up again because there are absolutely no other measures now to try and stop/slow the spread, ie test and trace.

Well except for a vaccine, but I don't think people are going to be happy to wait around in lockdown for 18 months at least for something that may or may not happen.
 
Originally 7 days struck me as the kind of compromise a state would reach when trying to balance between the actual infection risk, and what percentage of the workforce would be absent according to various models. I could sort of see the rationale behind it when they were mostly going for the 'anyone with any symptoms vaguely similar to Covid-19 should self-isolate'. But its not a number of days driven purely by medical knowledge, its a compromise. And then, just like with decisions to describe certain kinds of contacts as close only if they lasted at least 15 minutes, the arbitrary numbers we have chosen for a specific reason then end up getting treated as some kind of fundamental truth, rules the virus sticks to. When obviously it doesnt care about our rules and definitions. So its bloody stupid to take the 7 day value, which was a compromise for a particular situation, and then treat it as though this is the amount of time that actually confirmed cases who tested positive should isolate for, and that any longer is unnecessary.

So yeah, I would say its not wise. Its possible that they can get away with such things without it making a really large difference because so much of the transmission between people actually tends to happen earlier, in which case it would be another numbers game, another factor that went into the earlier compromise calculation. But its not what you would choose to do if you were actually trying to minimise the risk for every single person, its the sort of thing you might get away with if only looking at the very largest picture, and trying to dodge the very scariest scenarios with their terrible orders of magnitude. If tens of thousands of lives lost now matters, but hundreds still dont, all sorts of sloppy decisions can be gotten away with in that numbers game, and it is tempting for me to put the 7 days thing in that camp :(
Yep, spot on. The difference between '7 days from onset of symptoms' and '14 days from the cessation of symptoms' is obviously enormous. As you say, the former is to avoid calamity, but the latter is what places like South Korea and now New Zealand are insisting on as they aim for total elimination. That really struck me when I first heard of SK's current policy - test at the airport, ok, fair dos, but then 2 weeks in solitary if you test negative. Wow. But if you're after zero, that does make sense.

The right balance is going to depend on circumstances. SK's policy makes less sense here right now cos infection is still so widespread it would not be a sensible expenditure of resources. But the UK's 7-day rule is looking increasingly like a recipe for continuing spread. Worse, it looks like a cynical way to keep people working.
 
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I think the problem is not that we don't have an end date as such, but we just have no other plan as an alternative to lockdown which would mean we could come out of it.

It's plainly obvious to everyone, that as soon as either the govt say we can ease lockdown, or everyone just gets bored of it anyway, we're just going to see the numbers go up again because there are absolutely no other measures now to try and stop/slow the spread, ie test and trace.

Well except for a vaccine, but I don't think people are going to be happy to wait around in lockdown for 18 months at least for something that may or may not happen.
This is the frustration, yes. It's utterly mad. The docs in that zoom thing were all very polite and reasonable about it, but none of them had any idea how test and trace was going to be done. They'd clearly not been told/asked a thing about it.

It looks like we might fall out of lockdown in a similar way to how we fell into it, with the government acting reactively in response to the actions of people and organisations taking the lead. They're beyond pathetic.
 
These places could in principle free up existing hospitals to go back to more normal stuff without worrying about sealing off specific covid wards, but only if you've got enough staff. There aren't enough staff. Also diverting all covid patients to Nightingale hospitals is unrealistic when you consider there's going to be what, five of them? A large chunk of the population will not be within viable transport distance of one.
The point made by the doc who raised this (a GP who is lined up to work there but hasn't been needed yet) is that she worried that all the effort was put into these headline projects that look good on telly at the expense of other, more important things. She didn't think it was a bad thing per se, but she did question the priorities of the government that led to it.
 
I think the problem is not that we don't have an end date as such, but we just have no other plan as an alternative to lockdown which would mean we could come out of it.
It's plainly obvious to everyone, that as soon as either the govt say we can ease lockdown, or everyone just gets bored of it anyway, we're just going to see the numbers go up again because there are absolutely no other measures now to try and stop/slow the spread, ie test and trace.
Well except for a vaccine, but I don't think people are going to be happy to wait around in lockdown for 18 months at least for something that may or may not happen.

For the appearance of a workable vaccine, "18 months" (or "18 months at least"!!) is not set in stone.

That length of time is repeatedly suggested in all areas of the media, sometimes phrased as "a year to 18 months before we get a vaccine"

But on here, both elbows and Azrael (also others) have allowed for the possibility that a vaccine might become available sooner than that, given the vast amount of research now going on into vaccine development in various institutions in several countries.

Note the words I emphasised though.
All I'm suggesting is that "18 months" isn't (necessarily) an unchanging given.
 
You're right, William. However 18 months also isn't a given maximum either. It could take longer.

I am also hopeful about the power of the energy being put into this and its potential to produce results. But we shouldn't be relying on it. Strikes me that the UK government is kind of relying on some miracle science way out of their mess, rather than proactively taking the steps needed in case that doesn't happen.
 
For the appearance of a workable vaccine, "18 months" (or "18 months at least"!!) is not set in stone.

That length of time is repeatedly suggested in all areas of the media, sometimes phrased as "a year to 18 months before we get a vaccine"

But on here, both elbows and Azrael (also others) have allowed for the possibility that a vaccine might become available sooner than that, given the vast amount of research now going on into vaccine development in various institutions in several countries.

Note the words I emphasised though.
All I'm suggesting is that "18 months" isn't (necessarily) an unchanging given.

There's also a distinction between a tested, effective vaccine existing and it being available on the vast scale needed. International co-operation could also be a sticking point here.
 
You're right, William. However 18 months also isn't a given maximum either. It could take longer.

I am also hopeful about the power of the energy being put into this and its potential to produce results. But we shouldn't be relying on it. Strikes me that the UK government is kind of relying on some miracle science way out of their mess, rather than proactively taking the steps needed in case that doesn't happen.

Oh, I definitely agree with that in terms of the Government.
Just waiting for the vaccine is no policy at all :mad:
 
There's also a distinction between a tested, effective vaccine existing and it being available on the vast scale needed. International co-operation could also be a sticking point here.

Very fair point.
But (just IMO) I'm actually mildly positive about the prospects for international co-operation for something as vitally important and necessary as a (reliable) vaccine.
 
Oh, I definitely agree with that in terms of the Government.
Just waiting for the vaccine is no policy at all :mad:
I'm increasingly reaching the conclusion that this has been their approach to lockdown as well. Stay home, protect the NHS, and build the shiny new facilities. There, job done. No, not job done. Disaster averted temporarily. That's all. Now the work starts...
 
I hope UK industry manufactures piles of PPE and we can become more independent of foreign suppliers. I think scrubs, gowns and aprons could be relatively easily made. Recyclable and sterilisable visors also are already being made but probably not yet in enough volumes, surgical masks could be made here but I don't know about the higher spec 3M type. Gloves might be an issue of tooling and specialist machines to manufacture. I think at the moment the majority of rubber gloves are made in Asia with a fairly high level of automation.
 
I hope UK industry manufactures piles of PPE and we can become more independent of foreign suppliers. I think scrubs, gowns and aprons could be relatively easily made. Recyclable and sterilisable visors also are already being made but probably not yet in enough volumes, surgical masks could be made here but I don't know about the higher spec 3M type. Gloves might be an issue of tooling and specialist machines to manufacture. I think at the moment the majority of rubber gloves are made in Asia with a fairly high level of automation.
Plus, the obvious point made in the zoomcast - lovely smooth procurement chains break down during a crisis, so there is really no substitute for a good old-fashioned stockpile. It may look inefficient, but this isn't a capitalist business you are running. It is a public service. Empty hospital beds may also look inefficient, but they are also a necessary part of a well-run health service.

It is painfully obvious that the NHS has been cut back to the bone following principles of business management. Probably on the instruction of management consultants without a single medical qualification.
 
I'd be amazed if a vaccine was proved to work - and widely available - within 2-3 years. I really hope it will be, but the scale up in manufacturing from CT to worldwide volume will be a huge logistical problem.

I'm sure vaccines will be manufactured at risk but even so I'd expect they will only be available to older or vulnerable people for quiet some time.

About 8 years ago I worked on a team to cost a government funded flu vaccine manufacturing factory. The idea was the facility would sit unused ready to manufacture something like this. We developed costs and a project plan but the investment never happened.
 
I'd be amazed if a vaccine was proved to work - and widely available - within 2-3 years. I really hope it will be, but the scale up in manufacturing from CT to worldwide volume will be a huge logistical problem.

I'm sure vaccines will be manufactured at risk but even so I'd expect they will only be available to older or vulnerable people for quiet some time.

About 8 years ago I worked on a team to cost a government funded flu vaccine manufacturing factory. The idea was the facility would sit unused ready to manufacture something like this. We developed costs and a project plan but the investment never happened.

My gut reaction to the bolded bit is that 2 to 3 years is on the outside edge of extreme pessimism -- given the amount of research currently going on.

I've no more knowledge or prediction skills than you, but let's just say that I'm (somewhat) less pessimistic.
 
My gut reaction to the bolded bit is that 2 to 3 years is on the outside edge of extreme pessimism -- given the amount of research currently going on.

I've no more knowledge or prediction skills than you, but let's just say that I'm (somewhat) less pessimistic.

You are. I've worked in the pharmaceutical supply chain and product development for almost thirty years. Hope your right though :)
 
I'd be amazed if a vaccine was proved to work - and widely available - within 2-3 years. I really hope it will be, but the scale up in manufacturing from CT to worldwide volume will be a huge logistical problem.
Isn't the logistical problem of scaling up the bit that could be expedited in a way we have never seen before? This thing has brought the world to a halt - there is incentive for governments around the world to invest billions in making sure a vaccine, once made, becomes available asap at least in the countries that can afford those billions.

My worry would be less about us in the UK, and more about the distribution of a vaccine to poorer parts of the world. Bit like HIV drugs that took years and years to reach Africa. There will need to be pressure kept up to make this equitable.
 
I wonder about the integrity of the tests.
Or, it could be that there's nothing wrong with testing, but the results are mundane. As far as I understand (more than happy to be corrected), the presence of antibodies is something that develops over time post-infection, so variance between participants may not be so alarming. The article suggests that some people had levels below what was expected, but this is early research, so what would the yardstick be?
 
My gut reaction to the bolded bit is that 2 to 3 years is on the outside edge of extreme pessimism -- given the amount of research currently going on.

I've no more knowledge or prediction skills than you, but let's just say that I'm (somewhat) less pessimistic.
One leading UK group with a novel vaccine is expecting 18-24 months at best to go from where they are (post animal model/pre human trials) to verification, (hopefully) approval and mass production.

Another UK group's vaccine will enter human clinical trials later this week at a London hospital. The lead researcher was talking earlier today of the issues they will have in scaling up and thought it would take 2+ years to get to hundreds of millions of units.
 
surgical masks could be made here but I don't know about the higher spec 3M type.
I mentioned the other day that I know someone who works in a factory in Co Durham making the 95% 3M masks. Not sure, but I think that's the only place they are manufactured in Europe.

I spoke to him yesterday. I wasn't able to get anything scandalous out of him, but the basic picture is that the masks are being sent all over Europe, including but not especially the UK.

Think the issue, if there is one, is likely to be with the Government, though. There seems to be a pattern of supplies being offered and turned down. It would be unreasonable, in those circumstances, to expect manufacturers not to send their products to buyers that actually want them.
 
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