Asthma UK petition to get all asthmatics jab in next cohort

[moose]

They are into the over 50’s now so you should have had yours or it will be soon. Depends where you live to some degree. They are probably still doing the over 80’s in Littlehampton.

Still on the over 65s here, alas. My time will come - not like I can do anything different when I've had it, tbf, but I was hoping for Pfizer, and the supply must be almost gone, as there was only enough for 20m people.

 

[farmerbarleymow]

Still on the over 65s here, alas. My time will come - not like I can do anything different when I've had it, tbf, but I was hoping for Pfizer, and the supply must be almost gone, as there was only enough for 20m people.

I wonder if that's due to the average age where you live, so there are more older people? It seems odd that they're doing younger poeple here which isn't far away. Hope you get your vaccination soon though.

 

[Sunray]

Still on the over 65s here, alas. My time will come - not like I can do anything different when I've had it, tbf, but I was hoping for Pfizer, and the supply must be almost gone, as there was only enough for 20m people.

Both are excellent vaccines

Official figures from Public health Scotland ( 1 million people )
Fourth week after first dose,
reduced risk of hospitalisation Pfizer, down 84% (n = 650,000)
Oxford-AstraZeneca, down 94% (n = 490,000)
Combined reduction in over 80s
Vaccination associated with 81% reduction in hospitalisation risk in the fourth week

 

[moose]

Sunray Yes, they're all good, but my inner science geek was hoping for an mRNA rather than adenoviral vector.
But current estimate is that I'll get it mid-April, so might be the single-dose vector J&J by then

 

[two sheds]

Is there any difference in the vaccines themselves that might explain the seemingly different reactions?

 

[moose]

Is there any difference in the vaccines themselves that might explain the seemingly different reactions?

Yes. Some are the new type messenger RNA (mRNA) vaccines and some are the older type adenoviral vector vaccines. There's a guide here, which is probably slightly biased because it's on Pfizer's website, but it explains the key differences Behind the Science: what is an mRNA Vaccine?

 

[Sunray]

Sunray Yes, they're all good, but my inner science geek was hoping for an mRNA rather than adenoviral vector.
But current estimate is that I'll get it mid-April, so might be the single-dose vector J&J by then

Apologies Moose, I have clearly forgotten everyone I know. I was a bit puzzled at you wanting a specific vaccine. Europeans are just sticking it in the fridge.

I can see the geeky attraction, decades and decades of biotech distilled down to 0.3ml of vaccine, held within lipid nanoparticles. Turning your own body into the machine which make the protein your immune system targets. Truly breathtaking stuff.

 

[William of Walworth]

Yes. Some are the new type messenger RNA (mRNA) vaccines and some are the older type adenoviral vector vaccines. There's a guide here, which is probably slightly biased because it's on Pfizer's website, but it explains the key differences Behind the Science: what is an mRNA Vaccine?

I've just read that link, and I think its content is hugely biased!

But as you said, and to be fair, it's pretty informative as well.

 

[platinumsage]

I've just read that link, and I think its content is hugely biased!

But as you said, and to be fair, it's pretty informative as well.

It might potentially be biased because the source is one manufacturer, but I can't see anything about it that is actually biased. Can you?

 

[farmerbarleymow]

It might potentially be biased because the source is one manufacturer, but I can't see anything about it that is actually biased. Can you?

This part of the graphic maybe implies a stronger T-cell response given it has two rather than one for the conventional vaccine. But it does show fewer antibodies.

 

[prunus]

This part of the graphic maybe implies a stronger T-cell response given it has two rather than one for the conventional vaccine. But it does show fewer antibodies.

View attachment 256540

NB the ‘conventional’ vaccine they are comparing against there isn’t how the adenovirus vectored ones work - they are more like the mRNA ones except they use a virus rather than a lipid Nanoparticle to deliver the spike protein template.

 

[moose]

I've just read that link, and I think its content is hugely biased!

But as you said, and to be fair, it's pretty informative as well.

Well it would be 'hugely' biased if they'd named their own drug, or they were the only manufacturer of mRNA vaccines, which they're not. It meets the regulatory requirements for fair balance.

 

[Treacle Toes]

I've got mild asthma. Not registered with a doctor. Can I get vaccine without being registered?

Given you need to be registered with the nhs to be called in for a vaccination I doubt it because it would involve mind reading and magic otherwise.

 

[Treacle Toes]

Registered now. I will go in for an asthma check up next week once they've got my details as it's been years.