A thing I have learned since watching the deer and its antics: they no longer apprehend you if you are wanted and come into contact with them. They did in IV, yes? What happens now? They just kill you? I think I read you don't respawn at the hospital anymore, but at a checkpoint? So would that be like the last mission checkpoint or if you slept in a bed?
I really wish they'd introduce proper saving. I hate hate hate it when games don't let you save whenever the fuck you want. There's no excuse for it. It's never anything other than frustrating. Particularly open world games like this.
I guess I could get on board with the idea of no saving if you're in the middle of a proper mission - to force some kind of consequence for fucking up. But not letting you save when just out and about is really annoying.